Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage
Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
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Biomedicines 2020, 8(11), 503; https://doi.org/10.3390/biomedicines8110503
Received: 2 November 2020
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Revised: 12 November 2020
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Accepted: 14 November 2020
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Published: 16 November 2020
(This article belongs to the Special Issue Experimental and Translational Research on Liver Disease)
Heparan sulfate is a highly sulfated polysaccharide abundant on the surface of hepatocytes and surrounding extracellular matrix. Emerging evidence demonstrates that heparan sulfate plays an important role in neutralizing the activities of proinflammatory damage associate molecular patterns (DAMPs) that are released from hepatocytes under pathological conditions. Unlike proteins and nucleic acids, isolation of homogenous heparan sulfate polysaccharides from biological sources is not possible, adding difficulty to study the functional role of heparan sulfate. Recent advancement in the development of a chemoenzymatic approach allows production of a large number of structurally defined oligosaccharides. These oligosaccharides are used to probe the physiological functions of heparan sulfate in liver damage under different pathological conditions. The findings provide a potential new therapeutic agent to treat liver diseases that are associated with excessive inflammation.
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Keywords:
heparan sulfate; chemoenzymatic synthesis; oligosaccharides; DAMPS; inflammation
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MDPI and ACS Style
Arnold, K.; Liao, Y.-E.; Liu, J. Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage. Biomedicines 2020, 8, 503. https://doi.org/10.3390/biomedicines8110503
AMA Style
Arnold K, Liao Y-E, Liu J. Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage. Biomedicines. 2020; 8(11):503. https://doi.org/10.3390/biomedicines8110503
Chicago/Turabian StyleArnold, Katelyn, Yi-En Liao, and Jian Liu. 2020. "Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage" Biomedicines 8, no. 11: 503. https://doi.org/10.3390/biomedicines8110503
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