Genistein Loaded Nanofibers Protect Spinal Cord Tissue Following Experimental Injury in Rats
AbstractInnovative drug-delivery systems offer a unique approach to effectively provide therapeutic drug dose over the needed time to achieve better tissue protection and enhanced recovery. The hypothesis of the current study was to test the antioxidant and anti-inflammatory effects of genistein and nanofibers on the spinal cord tissue following experimental spinal cord injury (SCI). Rats were treated post SCI with genistein that is loaded on chitosan/polyvinyl alcohol (CS/PVA) nanofibers as an implantable drug-delivery system. SCI caused marked oxidative damage and inflammation, as is evident by the reduction in the super oxide dismutase (SOD) activity and the level of interleukin-10 (IL-10) in injured spinal cord tissue, as well as the significant increase in the levels of nitric oxide (NO), malondialdehyde (MDA), and tumor necrosis factor-alpha (TNF-α). Treatment of rats post SCI with genistein and CS/PVA nanofibers improved most of the above-mentioned biochemical parameters and shifted them toward the control group values. Genistein induced an increase in the activity of SOD and the level of IL-10, while causing a decrease in NO, MDA, and TNF-α in injured spinal cord tissue. Genistein and CS/PVA nanofibers provide a novel combination for treating inflammatory nervous tissue conditions, especially when combined as an implantable drug-delivery system. View Full-Text
Share & Cite This Article
Ismail, M.; Ibrahim, S.; El-Amir, A.; EL-Rafei, A.M.; Allam, N.K.; Abdellatif, A. Genistein Loaded Nanofibers Protect Spinal Cord Tissue Following Experimental Injury in Rats. Biomedicines 2018, 6, 96.
Ismail M, Ibrahim S, El-Amir A, EL-Rafei AM, Allam NK, Abdellatif A. Genistein Loaded Nanofibers Protect Spinal Cord Tissue Following Experimental Injury in Rats. Biomedicines. 2018; 6(4):96.Chicago/Turabian Style
Ismail, Mohamed; Ibrahim, Sara; El-Amir, Azza; EL-Rafei, Amira M.; Allam, Nageh K.; Abdellatif, Ahmed. 2018. "Genistein Loaded Nanofibers Protect Spinal Cord Tissue Following Experimental Injury in Rats." Biomedicines 6, no. 4: 96.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.