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Genistein Loaded Nanofibers Protect Spinal Cord Tissue Following Experimental Injury in Rats

1
Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt
2
Energy Materials Laboratory, School of Sciences and Engineering, American University in Cairo, New Cairo 11835, Egypt
3
Supplementary General Science, Faculty of Oral and Dental Medicine, Future University in Egypt, New Cairo 11835, Egypt
4
Refractories, Ceramics and Building Materials Department, National Research Centre, Dokki, Giza 12622, Egypt
5
Biology Department, School of Sciences and Engineering, American University in Cairo, New Cairo 11835, Egypt
*
Authors to whom correspondence should be addressed.
Biomedicines 2018, 6(4), 96; https://doi.org/10.3390/biomedicines6040096
Received: 18 September 2018 / Revised: 28 September 2018 / Accepted: 1 October 2018 / Published: 4 October 2018
(This article belongs to the Section Neurologic Diseases)
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Abstract

Innovative drug-delivery systems offer a unique approach to effectively provide therapeutic drug dose over the needed time to achieve better tissue protection and enhanced recovery. The hypothesis of the current study was to test the antioxidant and anti-inflammatory effects of genistein and nanofibers on the spinal cord tissue following experimental spinal cord injury (SCI). Rats were treated post SCI with genistein that is loaded on chitosan/polyvinyl alcohol (CS/PVA) nanofibers as an implantable drug-delivery system. SCI caused marked oxidative damage and inflammation, as is evident by the reduction in the super oxide dismutase (SOD) activity and the level of interleukin-10 (IL-10) in injured spinal cord tissue, as well as the significant increase in the levels of nitric oxide (NO), malondialdehyde (MDA), and tumor necrosis factor-alpha (TNF-α). Treatment of rats post SCI with genistein and CS/PVA nanofibers improved most of the above-mentioned biochemical parameters and shifted them toward the control group values. Genistein induced an increase in the activity of SOD and the level of IL-10, while causing a decrease in NO, MDA, and TNF-α in injured spinal cord tissue. Genistein and CS/PVA nanofibers provide a novel combination for treating inflammatory nervous tissue conditions, especially when combined as an implantable drug-delivery system. View Full-Text
Keywords: genistein; nanofibers; spinal cord injury; inflammation SCI; SOD; NO; MDA; IL-10; TNF-α genistein; nanofibers; spinal cord injury; inflammation SCI; SOD; NO; MDA; IL-10; TNF-α
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ismail, M.; Ibrahim, S.; El-Amir, A.; EL-Rafei, A.M.; Allam, N.K.; Abdellatif, A. Genistein Loaded Nanofibers Protect Spinal Cord Tissue Following Experimental Injury in Rats. Biomedicines 2018, 6, 96.

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