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Pathogens and Their Effect on Exosome Biogenesis and Composition

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Microbiology Program, Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL 36104, USA
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Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL 36104, USA
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Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
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Center for NanoBiotechnology Research and Department of Biological Sciences, Alabama State University, Montgomery, AL 36104, USA
*
Author to whom correspondence should be addressed.
Biomedicines 2018, 6(3), 79; https://doi.org/10.3390/biomedicines6030079
Received: 25 May 2018 / Revised: 17 July 2018 / Accepted: 17 July 2018 / Published: 23 July 2018
Exosomes are nanosized membrane microvesicles (30–100 nm) that have the capability to communicate intercellularly and transport cell components (i.e., miRNA, mRNA, proteins and DNA). Exosomes are found in nearly every cell type (i.e., mast cells, dendritic, tumor, and macrophages). There have been many studies that have shown the importance of exosome function as well as their unique packaging and targeting abilities. These characteristics make exosomes ideal candidates to act as biomarkers and therapeutics for disease. We will discuss the biogenesis, composition, and relationship of exosomes with non-viral microbial infections including gram-negative bacteria, gram-positive bacteria, Leishmania and Trypanosoma cruzi. View Full-Text
Keywords: exosomes; Trypanosoma cruzi; bacteria; leishmaniasis; biomarker exosomes; Trypanosoma cruzi; bacteria; leishmaniasis; biomarker
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MDPI and ACS Style

Jones, L.B.; Bell, C.R.; Bibb, K.E.; Gu, L.; Coats, M.T.; Matthews, Q.L. Pathogens and Their Effect on Exosome Biogenesis and Composition. Biomedicines 2018, 6, 79.

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