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Physiological Signaling and Structure of the HGF Receptor MET

1
Department Translational Medicine, University Piemonte Orientale, via Solaroli 17, 28100 Novara, Italy
2
Università Vita-Salute San Raffaele, via Olgettina 58, 20132 Milano, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Zimmer Yitzhak
Biomedicines 2015, 3(1), 1-31; https://doi.org/10.3390/biomedicines3010001
Received: 30 September 2014 / Accepted: 9 December 2014 / Published: 31 December 2014
(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
The “hepatocyte growth factor” also known as “scatter factor”, is a multifunctional cytokine with the peculiar ability of simultaneously triggering epithelial cell proliferation, movement and survival. The combination of those proprieties results in the induction of an epithelial to mesenchymal transition in target cells, fundamental for embryogenesis but also exploited by tumor cells during metastatization. The hepatocyte growth factor receptor, MET, is a proto-oncogene and a prototypical transmembrane tyrosine kinase receptor. Inhere we discuss the MET molecular structure and the hepatocyte growth factor driven physiological signaling which coordinates epithelial proliferation, motility and morphogenesis. View Full-Text
Keywords: signaling pathways; tyrosine kinase receptor; protein–protein interaction; SH2 domain; post translational modification; signal transduction signaling pathways; tyrosine kinase receptor; protein–protein interaction; SH2 domain; post translational modification; signal transduction
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Baldanzi, G.; Graziani, A. Physiological Signaling and Structure of the HGF Receptor MET. Biomedicines 2015, 3, 1-31.

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