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Biomedicines
Volume 13
Issue 9
10.3390/biomedicines13092266
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Background:
Systematic Review

The Use of Platelet-Rich Fibrin in Combination with Synthetic Bone Grafting: A Systematic Review

by
Rosana Costa
1,2,*,
Alicia Carvalho
1,
Paula López-Jarana
1,2,
Vitória Costa
1,
Marta Relvas
1,2,
Filomena Salazar
1,2,
Tomás Infante da Câmara
1,
Miguel Nunes Vasques
1,2 and
Marco Infante da Câmara
1,2
1
Department of Medicine and Oral Surgery, University Institute of Health Sciences (IUCS-CESPU), 4585-116 Gandra, Portugal
2
Oral Pathology and Rehabilitation Research Unit (UNIPRO), University Institute of Health Sciences (IUCS-CESPU), 4585-116 Gandra, Portugal
*
Author to whom correspondence should be addressed.
Biomedicines 2025, 13(9), 2266; https://doi.org/10.3390/biomedicines13092266
Submission received: 28 July 2025 / Revised: 5 September 2025 / Accepted: 10 September 2025 / Published: 15 September 2025
(This article belongs to the Section Molecular and Translational Medicine)
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Abstract

Background: In atrophic posterior maxillary regions, sub-antral surgery is often used for rehabilitation with implants. In order to stimulate bone regeneration, autogenous, xenogenic, alloplastic and platelet-rich fibrin (PRF) grafts are commonly used. Aim: To assess the effectiveness of PRF alone or combination with synthetic bone substitutes on bone formation, implant stability, and survival in sub-antral surgery. Materials and Methods: A literature review was carried out from September 2024 to April 2025, according to PRISMA guidelines using the PubMed, Cochrane Library, Wiley, ScienceDirect, and Web of Science databases. From a total of 601 articles identified, 11 met the inclusion criteria and were selected for analysis. Results: PRF in combination with synthetic materials has shown potential benefits, especially in increasing biomechanical stability and bone formation. Although, most studies have not reported statistically significant differences when comparing the use of synthetic material alone against its combination with PRF. Discussion: The use of synthetic grafts in combination with PRF has become increasingly common in sub-antral implant procedures. PRF promotes angiogenesis, osteoprogenitor cell differentiation and bone regeneration, favouring the healing and remodelling process of the tissues, as well as greater stability and longevity of the implant. Conclusions: The combination of PRF with synthetic bone grafting shows promising results; however, further studies are needed to confirm the efficacy of PRF in maxillary sinus grafts in conjunction with the use of biomaterials.
Keywords: platelet-rich fibrin; sinus floor augmentation; bone substitutes; synthetic bone graft; synthetic hydroxyapatite; beta-tricalcium phosphate platelet-rich fibrin; sinus floor augmentation; bone substitutes; synthetic bone graft; synthetic hydroxyapatite; beta-tricalcium phosphate

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MDPI and ACS Style

Costa, R.; Carvalho, A.; López-Jarana, P.; Costa, V.; Relvas, M.; Salazar, F.; Infante da Câmara, T.; Nunes Vasques, M.; Infante da Câmara, M. The Use of Platelet-Rich Fibrin in Combination with Synthetic Bone Grafting: A Systematic Review. Biomedicines 2025, 13, 2266. https://doi.org/10.3390/biomedicines13092266

AMA Style

Costa R, Carvalho A, López-Jarana P, Costa V, Relvas M, Salazar F, Infante da Câmara T, Nunes Vasques M, Infante da Câmara M. The Use of Platelet-Rich Fibrin in Combination with Synthetic Bone Grafting: A Systematic Review. Biomedicines. 2025; 13(9):2266. https://doi.org/10.3390/biomedicines13092266

Chicago/Turabian Style

Costa, Rosana, Alicia Carvalho, Paula López-Jarana, Vitória Costa, Marta Relvas, Filomena Salazar, Tomás Infante da Câmara, Miguel Nunes Vasques, and Marco Infante da Câmara. 2025. "The Use of Platelet-Rich Fibrin in Combination with Synthetic Bone Grafting: A Systematic Review" Biomedicines 13, no. 9: 2266. https://doi.org/10.3390/biomedicines13092266

APA Style

Costa, R., Carvalho, A., López-Jarana, P., Costa, V., Relvas, M., Salazar, F., Infante da Câmara, T., Nunes Vasques, M., & Infante da Câmara, M. (2025). The Use of Platelet-Rich Fibrin in Combination with Synthetic Bone Grafting: A Systematic Review. Biomedicines, 13(9), 2266. https://doi.org/10.3390/biomedicines13092266

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