Clinical Performance of Analog and Digital 18F-FDG PET/CT in Pediatric Epileptogenic Zone Localization: Preliminary Results
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. PET/CT Acquisition Protocols
2.3. Qualitative Image Analysis
2.4. Quantitative Image Analysis
2.5. Statistical Analysis
2.6. Standard of Reference and Post-Surgical Outcome
3. Results
3.1. Visual and Quantitative Scoring, Interobserver Agreement
3.2. Correlation Between Visual and Z-Scores
3.3. Correlation Between PET and MRI Findings
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patient | Age | Sex | Epilepsy Duration (Years) | PET Device | PET Detection | EZ Location | MRI Findings | Histopathology | Engel Scale |
---|---|---|---|---|---|---|---|---|---|
1 | 11 | F | 2 | aPET | + | R temp | − | Gliosis | Class I |
2 | 13 | M | 3 | aPET | + | L temp | +/C | HS | Class I |
3 * | 17 | M | 6 | aPET | + | R temp-occip | +/C | Gliosis | Class I |
4 | 8 | M | 2 | aPET | − | L front | + | FCD | Class III |
5 | 11 | F | 3 | aPET | − | Left temp | + | HS | Class I |
6 | 10 | M | 4 | aPET | + | R temp | − | Gliosis | Class II |
7 | 9 | M | 2 | aPET | − | L front | + | FCD | Class I |
8 | 15 | M | 3 | aPET | + | L temp | +/C | HS | Class II |
9 | 13 | M | 4 | aPET | + | L temp | +/C | Temp cyst | Class I |
10 | 9 | F | 2 | aPET | + | R temp | − | HS | Class I |
11 | 12 | F | 3 | aPET | + | L front | +/C | FCD | Class II |
12 | 15 | M | 4 | dPET | + | R temp | +/C | HS | Class I |
13 | 7 | F | 2 | dPET | + | L front | +/C | FCD | Class I |
14 | 9 | M | 3 | dPET | + | R temp | − | HS | Class I |
15 | 11 | F | 4 | dPET | + | L temp | +/C | HS | Class I |
16 | 13 | F | 5 | dPET | + | R temp | − | HS | Class I |
17 | 10 | M | 2 | dPET | − | L front | + | FCD | Class I |
18 | 16 | M | 3 | dPET | + | R temp | +/C | HS | Class I |
19 | 12 | F | 3 | dPET | + | L temp | − | Gliosis | Class I |
20 | 10 | M | 2 | dPET | + | L temp | +/C | ODG WHO 2 | Class III |
21 | 9 | M | 3 | dPET | + | R temp | +/C | HS | Class II |
22 | 12 | F | 4 | dPET | + | L front-temp | − | Gliosis | Class I |
Device | Average Visual Scores | ICC | 95% (CI) | ||
---|---|---|---|---|---|
Observer 1 | Observer 2 | Observer 3 | |||
aPET | 2.1 ± 0.9 | 2.2 ± 1.1 | 2 ± 0.8 | 0.63 | 0.2–0.8 |
dPET | 3.1 ± 0.8 | 3 ± 1 | 3.1 ± 0.8 | 0.91 | 0.7–0.9 |
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Bagni, O.; Danieli, R.; Bianconi, F.; Palumbo, B.; Filippi, L. Clinical Performance of Analog and Digital 18F-FDG PET/CT in Pediatric Epileptogenic Zone Localization: Preliminary Results. Biomedicines 2025, 13, 1887. https://doi.org/10.3390/biomedicines13081887
Bagni O, Danieli R, Bianconi F, Palumbo B, Filippi L. Clinical Performance of Analog and Digital 18F-FDG PET/CT in Pediatric Epileptogenic Zone Localization: Preliminary Results. Biomedicines. 2025; 13(8):1887. https://doi.org/10.3390/biomedicines13081887
Chicago/Turabian StyleBagni, Oreste, Roberta Danieli, Francesco Bianconi, Barbara Palumbo, and Luca Filippi. 2025. "Clinical Performance of Analog and Digital 18F-FDG PET/CT in Pediatric Epileptogenic Zone Localization: Preliminary Results" Biomedicines 13, no. 8: 1887. https://doi.org/10.3390/biomedicines13081887
APA StyleBagni, O., Danieli, R., Bianconi, F., Palumbo, B., & Filippi, L. (2025). Clinical Performance of Analog and Digital 18F-FDG PET/CT in Pediatric Epileptogenic Zone Localization: Preliminary Results. Biomedicines, 13(8), 1887. https://doi.org/10.3390/biomedicines13081887