Next Article in Journal
Liquid Biopsy and Multi-Omic Biomarkers in Breast Cancer: Innovations in Early Detection, Therapy Guidance, and Disease Monitoring
Previous Article in Journal
Vascular Smooth Muscle Cell Metabolic Disorders in the Occurrence and Development of Aortic Aneurysms and Dissections: Implications for Therapy
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 13
Issue 12
10.3390/biomedicines13123074
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Clinical Remission in Severe Asthma: A Comparative Analysis of Patients with and Without Biologics from the Swiss Severe Asthma Registry

by
Fabienne Jaun
1,2,*,
Maria Boesing
1,2,
Giorgia Lüthi-Corridori
1,2,3,
Pierre-Olivier Bridevaux
4,
Florian Charbonnier
5,
Christian F. Clarenbach
6,
Jean-Marc Fellrath
7,
Pietro Gianella
8,
Anja Jochmann
9,
Lukas Kern
10,
Nikolay Pavlov
11,
Tsogyal Daniela Latshang
12,
Christophe Von Garnier
13 and
Joerg Daniel Leuppi
1,2,*
1
University Institute of Internal Medicine, Cantonal Hospital Baselland, 4410 Liestal, Switzerland
2
Medical Faculty, University of Basel, 4056 Basel, Switzerland
3
Center for Executive and Continuing Education, Harvard T.H. Chan School of Public Health—ECPE, Boston, MA 02115, USA
4
Centre Hospitalier du Valais Romand, 1951 Sion, Switzerland
5
University Clinic of Pneumology, University Hospital Geneva, 1205 Geneva, Switzerland
6
Department of Pulmonology, University Hospital Zurich, 8091 Zurich, Switzerland
7
Service of Pulmonology, Réseau Hospitalier Neuchâtelois, 2000 Neuchâtel, Switzerland
8
Pneumology Department, Ente Ospedaliero Cantonale, 6500 Lugano, Switzerland
9
Department of Pneumology, University Children Hospital Basel, 4031 Basel, Switzerland
10
Pneumology Department, Cantonal Hospital Winterthur, 8400 Winterthur, Switzerland
11
Department of Pulmonary Medicine, Allergology and Clinical Immunology Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
12
Pneumology Department, Cantonal Hospital Grisons, 7000 Chur, Switzerland
13
Division of Pulmonology, Department of Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland
 
add Show full affiliation list
 
remove Hide full affiliation list
*
Authors to whom correspondence should be addressed.
Biomedicines 2025, 13(12), 3074; https://doi.org/10.3390/biomedicines13123074 (registering DOI)
Submission received: 24 October 2025 / Revised: 9 December 2025 / Accepted: 9 December 2025 / Published: 12 December 2025
(This article belongs to the Special Issue Asthma and Allergy: New Therapeutic Frontiers and Patient Perspectives in a Changing World)
Review Reports Versions Notes

Abstract

Background: Severe asthma is a complex chronic airway disease. Biologic therapies are targeted monoclonal antibody treatments used in patients with uncontrolled, severe asthma, but real-world data from long-term registries and on patients who remain biologic-naïve are limited. This study compared severe asthma patients with and without biologic therapy and identified predictors of key clinical remission components. Methods: In this cross-sectional analysis of adult patients from the Swiss Severe Asthma Registry (SSAR), we compared patients treated with a biologic for ≥6 months to biologic-naïve patients (never exposed to biologics). Baseline characteristics were summarized descriptively. Multivariable logistic regression was used to identify predictors of four remission components: good asthma control (ACT ≥ 20), absence of exacerbations, no maintenance oral corticosteroid (OCS) use, and preserved lung function (FEV1 > 80% predicted). Results: Of 394 patients, 298 (75.6%) were biologic-treated and 96 (24.4%) were biologic-naïve. Biologic-treated patients more often had allergic asthma and type-2–related comorbidities, and showed better outcomes, including fewer exacerbations (0.49 vs. 1.09/year; p < 0.001) and higher ACT scores (20.0 vs. 17.2; p < 0.001). Biologic therapy was independently associated with higher odds of asthma control (OR 3.96; p = 0.006), no exacerbations (OR 5.11; p = 0.001), no OCS use (OR 6.27; p = 0.002), and FEV1 > 80% predicted (OR 4.42; p = 0.011). Overall, 24.2% of biologic-treated patients and 6.2% of biologic-naïve patients fulfilled all four remission components. Conclusions: In this real-world registry cohort, biologic-treated patients were more likely to meet individual and composite remission criteria than biologic-naïve patients. The relatively low proportion of patients achieving all four stringent criteria highlights the need to revisit current remission definitions and to adopt individualized, multidimensional treatment goals in severe asthma.
Keywords: severe asthma; clinical remission; asthma remission; real-world evidence severe asthma; clinical remission; asthma remission; real-world evidence

Share and Cite

MDPI and ACS Style

Jaun, F.; Boesing, M.; Lüthi-Corridori, G.; Bridevaux, P.-O.; Charbonnier, F.; Clarenbach, C.F.; Fellrath, J.-M.; Gianella, P.; Jochmann, A.; Kern, L.; et al. Clinical Remission in Severe Asthma: A Comparative Analysis of Patients with and Without Biologics from the Swiss Severe Asthma Registry. Biomedicines 2025, 13, 3074. https://doi.org/10.3390/biomedicines13123074

AMA Style

Jaun F, Boesing M, Lüthi-Corridori G, Bridevaux P-O, Charbonnier F, Clarenbach CF, Fellrath J-M, Gianella P, Jochmann A, Kern L, et al. Clinical Remission in Severe Asthma: A Comparative Analysis of Patients with and Without Biologics from the Swiss Severe Asthma Registry. Biomedicines. 2025; 13(12):3074. https://doi.org/10.3390/biomedicines13123074

Chicago/Turabian Style

Jaun, Fabienne, Maria Boesing, Giorgia Lüthi-Corridori, Pierre-Olivier Bridevaux, Florian Charbonnier, Christian F. Clarenbach, Jean-Marc Fellrath, Pietro Gianella, Anja Jochmann, Lukas Kern, and et al. 2025. "Clinical Remission in Severe Asthma: A Comparative Analysis of Patients with and Without Biologics from the Swiss Severe Asthma Registry" Biomedicines 13, no. 12: 3074. https://doi.org/10.3390/biomedicines13123074

APA Style

Jaun, F., Boesing, M., Lüthi-Corridori, G., Bridevaux, P.-O., Charbonnier, F., Clarenbach, C. F., Fellrath, J.-M., Gianella, P., Jochmann, A., Kern, L., Pavlov, N., Latshang, T. D., Von Garnier, C., & Leuppi, J. D. (2025). Clinical Remission in Severe Asthma: A Comparative Analysis of Patients with and Without Biologics from the Swiss Severe Asthma Registry. Biomedicines, 13(12), 3074. https://doi.org/10.3390/biomedicines13123074

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop