Airway Epithelium Senescence as a Driving Mechanism in COPD Pathogenesis
Abstract
:1. Introduction
2. Cellular Senescence and the COPD Airway Epithelium
3. Mechanisms of Airway Epithelial Cellular Senescence in COPD
3.1. DNA Damage-Induced Senescence on COPD Airway Epithelium
3.2. Oxidative-Stress-Induced Senescence on COPD Airway Epithelium
3.3. Reduced Autophagy
3.4. SASP Further Accelerates Senescence and COPD Inflammation
4. Therapeutics Targeting Senescence
4.1. Inhibition of Prosurvival Pathways
4.2. Inhibition of mTOR
4.3. Micro-RNAs
4.4. Extracellular Vesicles
4.5. Telomere Shortening
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Bateman, G.; Guo-Parke, H.; Rodgers, A.M.; Linden, D.; Bailey, M.; Weldon, S.; Kidney, J.C.; Taggart, C.C. Airway Epithelium Senescence as a Driving Mechanism in COPD Pathogenesis. Biomedicines 2023, 11, 2072. https://doi.org/10.3390/biomedicines11072072
Bateman G, Guo-Parke H, Rodgers AM, Linden D, Bailey M, Weldon S, Kidney JC, Taggart CC. Airway Epithelium Senescence as a Driving Mechanism in COPD Pathogenesis. Biomedicines. 2023; 11(7):2072. https://doi.org/10.3390/biomedicines11072072
Chicago/Turabian StyleBateman, Georgia, Hong Guo-Parke, Aoife M. Rodgers, Dermot Linden, Melanie Bailey, Sinéad Weldon, Joseph C. Kidney, and Clifford C. Taggart. 2023. "Airway Epithelium Senescence as a Driving Mechanism in COPD Pathogenesis" Biomedicines 11, no. 7: 2072. https://doi.org/10.3390/biomedicines11072072