Association between Organochlorine Pesticides and Vitamin D in Female Subjects
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Recruitment
2.2. OCP Measurement
2.3. Instrumental Analysis
2.4. Quality Assurance/Quality Control
2.5. Vitamin D3 and Biochemical Parameters
2.6. CaM Proteomic Measurement
2.7. Statistics
3. Results
3.1. Whole-Cohort Analysis
3.2. OCP Levels
3.3. Whole-Group Correlations
3.4. Sufficient and Deficient 25(OH)D3 Subgroup Correlations
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Female Subjects (n = 58) | ||
---|---|---|
Mean | SD | |
Age (years) | 31.9 | 4.6 |
BMI (kg/m2) | 25.7 | 3.7 |
CRP (mg/L) | 2.6 | 2.5 |
TSH (mU/L) | 2.4 | 2.2 |
Free-T3 (pmol/L) | 4.8 | 0.7 |
Free-T4 (pmol/L) | 11.3 | 1.8 |
25(OH)D3 (ng/mL) | 23 | 11.2 |
1,25(OH)2D3 (ng/mL) | 0.05 | 0.02 |
Calcium (mmol/L) | 2.3 | 0.07 |
Urea (nmol/L) | 4.66 | 5.21 |
Creatinine (nmol/L) | 66 | 8.86 |
eGFR (mL/min/1.73 m2) | 92.3 | 14.8 |
PDE1A (RFU) | 789 | 1060 |
CAMK2A (RFU) | 373 | 453 |
CaMK2B (RFU) | 859 | 1423 |
CaMK1D (RFU) | 1695 | 580 |
CaMK2D (RFU) | 2379 | 3462 |
CaMK1 (RFU) | 4681 | 1371 |
CaMKK α (RFU) | 343 | 463 |
PeCB (ng/g Lipid) | 9.12 | 9.1 |
α-HCH (ng/g Lipid) | <LOR | |
β-HCH (ng/g Lipid) | 4.63 | 4.92 |
HCB (ng/g Lipid) | 9.81 | 6.5 |
Lindane (ng/g Lipid) | 1.35 | 0.28 |
Trans-Chlordane (ng/g Lipid) | 1.4 | 0.97 |
cis-Chlordane (ng/g Lipid) | 1.59 | 0.58 |
p,p′-DDE (ng/g Lipid) | 40.7 | 60.4 |
o,p′-DDE (ng/g Lipid) | 2.23 | 0.32 |
o,p′-DDD (ng/g Lipid) | <LOR | |
p,p′-DDD+o,p′-DDT (ng/g Lipid) | <LOR | |
p,p′-DDT (ng/g Lipid) | 4.99 | 2.3 |
Mirex (ng/g Lipid) | 3.27 | 0.69 |
ƩOCPs (ng/g Lipid) | 63.3 | 66.8 |
PeCB | β-HCH | HCB | Lindane | trans-Chlordane | cis-Chlordane | o,p′-DDE | p,p′-DDE | p,p′-DDT | Mirex | ƩOCPs | |
---|---|---|---|---|---|---|---|---|---|---|---|
25(OH)D3 | 0.289 | 0.174 | 0.101 | 0.393 | −0.14 | 0.325 | 0.374 | 0.272 | 0.096 | −0.204 | 0.284 |
(0.192) | (0.339) | (0.502) | (0.40) | (0.648) | (0.091) | (0.258) | (0.061) | (0.595) | (0.361) | (0.051) | |
1,25(OH)2D3 | −0.108 | 0.315 | 0.333 | −0.2 | −0.205 | 0.278 | 0.06 | 0.408 | 0.364 | −0.03 | 0.34 |
(0.66) | (0.14) | (0.05) | (0.92) | (0.74) | 0.263 | (0.89) | (0.01) | (0.09) | (0.92) | (0.04) |
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Brennan, E.; Butler, A.E.; Nandakumar, M.; Drage, D.S.; Sathyapalan, T.; Atkin, S.L. Association between Organochlorine Pesticides and Vitamin D in Female Subjects. Biomedicines 2023, 11, 1451. https://doi.org/10.3390/biomedicines11051451
Brennan E, Butler AE, Nandakumar M, Drage DS, Sathyapalan T, Atkin SL. Association between Organochlorine Pesticides and Vitamin D in Female Subjects. Biomedicines. 2023; 11(5):1451. https://doi.org/10.3390/biomedicines11051451
Chicago/Turabian StyleBrennan, Edwina, Alexandra E. Butler, Manjula Nandakumar, Daniel S. Drage, Thozhukat Sathyapalan, and Stephen L. Atkin. 2023. "Association between Organochlorine Pesticides and Vitamin D in Female Subjects" Biomedicines 11, no. 5: 1451. https://doi.org/10.3390/biomedicines11051451