Zinc Finger E-Box Binding Homeobox Family: Non-Coding RNA and Epigenetic Regulation in Gliomas
Abstract
:1. Introduction
2. MiRNA Targeting ZEBs
2.1. MiR-200 Family
2.2. Cancer Stem Cell
2.3. Predicting Prognosis
2.4. MiRNAs as Therapeutic Targets
3. LncRNA Affecting ZEBs
3.1. Hypoxia-Induced EMT
3.2. ZEB1-AS1
3.3. TGF-β
3.4. LncRNA Contributes to EMT-Dependetnt Chemoresistance
3.5. LncRNA Controlled by ZEB
4. Epigenetic Regulation of ZEBs
5. Discussion and Future Perspectives
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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miRNA | Expression in Glioma * | Role in Gliomagenesis | Downstream Targets | Upstream Regulators | Biological Function in Glioma Cells | Reported Prognostic Value ** | Refs. |
---|---|---|---|---|---|---|---|
miR-590-3p | Down | Tumour suppressor | ZEB1, ZEB2, N-cadherin, Vimentin, E-cadherin | - | Inhibit migration, invasion | - | [35] |
miR-940 | Down | Tumour suppressor | ZEB2, N-cadherin, Vimentin, Fibronectin, α-SMA, MMP2, E-cadherin | - | Inhibit migration, invasion | - | [36] |
miR-205 | Down | Tumour suppressor | ZEB1/Akt/mTOR, E-cadherin, N-cadherin, Vimentin | - | Inhibit migration, invasion | YES | [37,38] |
miR-200a | Down | Tumour suppressor | ZEB1/TF | MYC, H19 | Inhibit proliferation, migration | - | [39,40,41] |
miR-200c | Down | Tumour suppressor | ZEB1/E-cadherin, EGFR, ZEB2 | EGFR, MeCP2 /SUV39H1, ZEB1-AS1, LINC00115 | Inhibit migration, proliferation, promote apoptosis | - | [42,43,44,45,46,47] |
miR-141 | Down | Tumour suppressor | ZEB1 | ZEB1-AS1 | Inhibit migration, proliferation, promote apoptosis | - | [42,46] |
miR-203 | - | Tumour suppressor | ADAMDEC1 | ADAMDEC1/FGF2/FGFR1/ERK1/2/ZEB1 | - | - | [48] |
miR-622 | Down | Tumour suppressor | ZEB2 | - | Inhibit proliferation, migration, invasion, promote apoptosis | YES | [49] |
miR-769-3p | Down | Tumour suppressor | ZEB2/Wnt /β-catenin | - | Inhibit proliferation, migration, invasion | YES | [50] |
miR-139 | Down | Tumour suppressor | ZEB1 | - | Inhibit migration, invasion | - | [51] |
lnRNA | Expression in Glioma * | Role in Gliomagenesis | Downstream Targets | Upstream Regulators | Biological Function in Glioma Cells | Reported Prognostic Value ** | Refs. |
---|---|---|---|---|---|---|---|
SNHG5 | Up | Oncogene | miR-205-5p/ZEB2 | - | Promote proliferation | - | [88] |
HOTAIRM1 | - | Oncogene | miR-873-5p/ZEB2 | - | Promote proliferation, inhibit apoptosis | YES | [89] |
UCA1 | - | Oncogene | miR-204-5p/ZEB1, Fibronectin, COL5 A1 | - | Promote migration, invasion | - | [90] |
MALAT1 | Up | Oncogene | miR-124/ZEB2, ZEB1, MDR1, MRP5, LRP1, E-cadherin, ZO-1, α-SMA, Fibronectin | - | Promote proliferation, inhibit cell cycle arrest, inhibit apoptosis | YES | [91,92] |
HOXC-AS2 | Up | Oncogene | miR-876-5p/ZEB1, Vimentin, N-cadherin | ZEB1 | Promote migration, invasion | YES | [93] |
LINC00511 | Up | Oncogene | miR-524-5p/YB1/ZEB1, Cyclin D1, CDK4, Vimentin, N-cadherin, E-cadherin | ZEB1 | Promote proliferation, migration, invasion, inhibit cell cycle arrest | YES | [94] |
H19 | Up | Oncogene | miR-200a/CDK6/ZEB1 | - | Promote proliferation, invasion, migration | - | [41] |
HOTTIP | - | Oncogene | miR-10b/ZEB1/ZEB2 /E-cadherin, VEGF, MMP-9, Vimentin, miR-101/ZEB1 | HIF-1α | Promote chemoresistance, proliferation, migration, invasion angiogenesis, metastasis | YES | [95,96] |
OR7E156P | Up | Oncogene | miR-143/HIF-1α/ZEB1 /VEGF, Snail, Vimentin | - | Promote invasion, proliferation | YES | [97] |
ZEB1-AS1 | Up | Oncogene | ZEB1, Snail, MMP2, MMP9, N-cadherin, Integrin-β1, Vimentin, E-cadherin, Cyclin D1, CDK2, Rb, Bax, Bcl-2, miR-200c/miR-141 /ZEB1, miR-577 | - | Promote proliferation, invasion, migration, inhibit cell cycle arrest inhibit apoptosis | YES | [46,98,99,100] |
LINC00115 | Up | Oncogene | miR-200s/ZEB1, Vimentin, E-cadherin miR-200s/ZNF596 /EZH2/STAT3 | TGF-β | Promote proliferation | YES | [47] |
LINC00645 | Up | Oncogene | miR-205-3p/ZEB1, Snail, Vimentin, N-cadherin, E-cadherin, Bcl-2, Bax | TGF-β | Promote proliferation, migration, invasion, inhibit apoptosis | YES | [101] |
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Lenda, B.; Żebrowska-Nawrocka, M.; Turek, G.; Balcerczak, E. Zinc Finger E-Box Binding Homeobox Family: Non-Coding RNA and Epigenetic Regulation in Gliomas. Biomedicines 2023, 11, 1364. https://doi.org/10.3390/biomedicines11051364
Lenda B, Żebrowska-Nawrocka M, Turek G, Balcerczak E. Zinc Finger E-Box Binding Homeobox Family: Non-Coding RNA and Epigenetic Regulation in Gliomas. Biomedicines. 2023; 11(5):1364. https://doi.org/10.3390/biomedicines11051364
Chicago/Turabian StyleLenda, Bartosz, Marta Żebrowska-Nawrocka, Grzegorz Turek, and Ewa Balcerczak. 2023. "Zinc Finger E-Box Binding Homeobox Family: Non-Coding RNA and Epigenetic Regulation in Gliomas" Biomedicines 11, no. 5: 1364. https://doi.org/10.3390/biomedicines11051364