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Biomedicines
Volume 11
Issue 5
10.3390/biomedicines11051311
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Communication

Histopathological Characterization of Abdominal Aortic Aneurysms from Patients with Multiple Aneurysms Compared to Patients with a Single Abdominal Aortic Aneurysm

by
Daniel Körfer
1,*,
Philipp Erhart
1,
Susanne Dihlmann
1,
Maani Hakimi
2,
Dittmar Böckler
1 and
Andreas S. Peters
1,3
1
Department of Vascular and Endovascular Surgery, University Hospital, 69120 Heidelberg, Germany
2
Department of Vascular Surgery, Lucerne Cantonal Hospital, 6000 Lucerne, Switzerland
3
Vaskuläre Biomaterialbank Heidelberg (VBBH), University Hospital, 69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
Biomedicines 2023, 11(5), 1311; https://doi.org/10.3390/biomedicines11051311
Submission received: 3 April 2023 / Revised: 26 April 2023 / Accepted: 27 April 2023 / Published: 28 April 2023
(This article belongs to the Special Issue The Role of Cytokines in Health and Disease)
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Abstract

The aim of this study was to investigate histopathological differences in abdominal aortic aneurysms (AAAs) between patients with multiple and single arterial aneurysms, as we suspect that there are different underlying mechanisms in aneurysm formation. Analysis was based on a previous retrospective study on patients with multiple arterial aneurysms (mult-AA; defined as at least four, n = 143) and a single AAA (sing-AAA, n = 972) who were admitted to our hospital for treatment between 2006 and 2016. Available paraffin-embedded AAA wall specimens were derived from the Vascular Biomaterial Bank Heidelberg (mult-AA, n = 12 vs. sing-AAA, n = 19). Sections were analyzed regarding structural damage of the fibrous connective tissue and inflammatory cell infiltration. Alterations to the collagen and elastin constitution were assessed by Masson–Goldner trichrome and Elastica van Gieson staining. Inflammatory cell infiltration, response and transformation were assessed by CD45 and IL-1β immunohistochemistry and von Kossa staining. The extent of aneurysmal wall alterations was assessed by semiquantitative gradings and was compared between the groups using Fisher’s exact test. IL-1β was significantly more present in the tunica media in mult-AA compared to sing-AAA (p = 0.022). The increased expression of IL-1β in mult-AA compared to sing-AAA indicates inflammatory processes play a role in aneurysm formation in patients with multiple arterial aneurysms.
Keywords: abdominal aortic aneurysm; vascular diseases; molecular pathology; interleukin-1beta abdominal aortic aneurysm; vascular diseases; molecular pathology; interleukin-1beta

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MDPI and ACS Style

Körfer, D.; Erhart, P.; Dihlmann, S.; Hakimi, M.; Böckler, D.; Peters, A.S. Histopathological Characterization of Abdominal Aortic Aneurysms from Patients with Multiple Aneurysms Compared to Patients with a Single Abdominal Aortic Aneurysm. Biomedicines 2023, 11, 1311. https://doi.org/10.3390/biomedicines11051311

AMA Style

Körfer D, Erhart P, Dihlmann S, Hakimi M, Böckler D, Peters AS. Histopathological Characterization of Abdominal Aortic Aneurysms from Patients with Multiple Aneurysms Compared to Patients with a Single Abdominal Aortic Aneurysm. Biomedicines. 2023; 11(5):1311. https://doi.org/10.3390/biomedicines11051311

Chicago/Turabian Style

Körfer, Daniel, Philipp Erhart, Susanne Dihlmann, Maani Hakimi, Dittmar Böckler, and Andreas S. Peters. 2023. "Histopathological Characterization of Abdominal Aortic Aneurysms from Patients with Multiple Aneurysms Compared to Patients with a Single Abdominal Aortic Aneurysm" Biomedicines 11, no. 5: 1311. https://doi.org/10.3390/biomedicines11051311

APA Style

Körfer, D., Erhart, P., Dihlmann, S., Hakimi, M., Böckler, D., & Peters, A. S. (2023). Histopathological Characterization of Abdominal Aortic Aneurysms from Patients with Multiple Aneurysms Compared to Patients with a Single Abdominal Aortic Aneurysm. Biomedicines, 11(5), 1311. https://doi.org/10.3390/biomedicines11051311

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