Mechanisms of COVID-19 Associated Pulmonary Thrombosis: A Narrative Review

Round 1

Reviewer 1 Report

the manuscript is interesting, generally well written and well illustrated. Only minor comments are necessary. In particular: 

Introduction: it deserves to be mentioned that SARS-CoV-2 can also lead to non restiratory diseases such as Preeclampsia, male infertility and brain damage (as recently reviewed PMID: 35114008, 35943095, 32934351). This is an important point to add since it highlights the fact that the cytokine storm found in COVID-19 patients can also damage other organs.

A table summarizing the studies discussed in the manuscript should be added.

Author Response

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Author Response File: Author Response.docx

Reviewer 2 Report

The Romanian authors summarized the current knowledge on the pathomechanisms of pulmonary thrombosis in the course of COVID-19. Although this clinical problem is widely known, the narrative review by Dr. Cristian-Mihail Niculae and colleagues is meticulous and describes in detail the individual elements leading to blood clotting disorders in COVID-19.

The paper lacks data that TEG and ROTEM provide in severe COVID-19. Authors, e.g., as the final subsection of a manuscript, may raise this issue using the following publications:

doi: 10.1055/a-1346-3178.

doi: 10.3390/life12101658.

doi: 10.3390/ijms24054319

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

The authors have addressed all my concerns.