Impact of Portal Vein Resection (PVR) in Patients Who Underwent Curative Intended Pancreatic Head Resection
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Clinical and Demographic Data
3.2. Histopathological Work-Up and Patients’ Outcome
3.3. PVR and Patients’ Outcome
3.4. Impact of Tumor Infiltration of the Portal Vein
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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n = 90 | Percentage | PVR | non-PVR | ||
---|---|---|---|---|---|
Type of surgery | |||||
PPPD | 76 | 84.4% | 41 (53.9%) | 35 (46.1%) | |
Whipple | 6 | 6.7% | 3 (50%) | 3 (50%) | |
TP | 8 | 8.9% | 6 (75%) | 2 (25%) | |
Portal vein resection | 50 | 55.6% | |||
Wedge Resection | 13 | 26% | |||
Complete resection | 37 | 74% | |||
Patients with surgical complications | 23 | 25.6% | |||
POPF | 15 | 16.7% | 6 (40%) | 9 (60%) | |
DGE | 7 | 7.8% | 2 (28.6%) | 5 (71.4%) | |
Postoperative bleeding | 7 | 7.8% | 3 (42.9%) | 4 (57.1%) | |
Leakage of bile duct anastomosis | 4 | 4.4% | 1 (25%) | 3 (75%) | |
Neoadjuvant treated patients | 7 | 7.8% | 2 (28.6%) | 5 (71.4%) | |
Adjuvant treated patients | 63 | 70% | 34 (68%) | 29 (72.5%) | |
FOLFIRINOX | 5 | 5 | 0 | ||
Gemcitabine | 43 | 19 | 24 | ||
Gemcitabine/Capecitabine | 11 | 8 | 3 | ||
Gemcitabine/nab-paclitaxel | 3 | 1 | 2 | ||
Capecitabine | 1 | 1 | 0 | ||
(y)pT-Stage | |||||
T0 | 2 | 2.2% | 0 (0%) | 2 (100%) | |
T1 | 4 | 4.5% | 1 (25%) | 3 (75%) | |
T2 | 21 | 23.3% | 15 (71.4%) | 6 (28.6%) | |
T3 | 63 | 70% | 34 (54%) | 29 (46%) | |
T4 | 0 | 0% | - | - | |
(y)pN-Stage | |||||
N0 | 25 | 27.8% | 11 (44%) | 14 (56%) | |
N1 | 56 | 62.2% | 32 (57.1%) | 24 (42.9%) | |
N2 | 9 | 10% | 7 (77.8%) | 2 (22.2%) | |
Grading | |||||
G1 | 1 | 1.1% | 0 (0%) | 1 (100%) | |
G2 | 65 | 72.2% | 39 (60%) | 26 (40%) | |
G3 | 22 | 24.5% | 11 (50%) | 11 (50%) | |
GX | 2 | 2.2% | 0 (0%) | 2 (100%) | |
Resection margin | |||||
R0 | 58 | 64.4% | 28 (48.3%) | 30 (51.7%) | |
CRM+ | 19 | 33.8% | 13 (68.4%) | 6 (31.6%) | |
CRM− | 24 | 41.4% | 7 (29.2%) | 17 (70.8%) | |
CRMx | 15 | 25.8% | 8 (53.3%) | 7 (46.7%) | |
R1 | 32 | 35.6% | 22 (68.8%) | 10 (31.1%) |
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Bernhardt, M.; Rühlmann, F.; Azizian, A.; Kölling, M.A.; Beißbarth, T.; Grade, M.; König, A.O.; Ghadimi, M.; Gaedcke, J. Impact of Portal Vein Resection (PVR) in Patients Who Underwent Curative Intended Pancreatic Head Resection. Biomedicines 2023, 11, 3025. https://doi.org/10.3390/biomedicines11113025
Bernhardt M, Rühlmann F, Azizian A, Kölling MA, Beißbarth T, Grade M, König AO, Ghadimi M, Gaedcke J. Impact of Portal Vein Resection (PVR) in Patients Who Underwent Curative Intended Pancreatic Head Resection. Biomedicines. 2023; 11(11):3025. https://doi.org/10.3390/biomedicines11113025
Chicago/Turabian StyleBernhardt, Markus, Felix Rühlmann, Azadeh Azizian, Max Alexander Kölling, Tim Beißbarth, Marian Grade, Alexander Otto König, Michael Ghadimi, and Jochen Gaedcke. 2023. "Impact of Portal Vein Resection (PVR) in Patients Who Underwent Curative Intended Pancreatic Head Resection" Biomedicines 11, no. 11: 3025. https://doi.org/10.3390/biomedicines11113025
APA StyleBernhardt, M., Rühlmann, F., Azizian, A., Kölling, M. A., Beißbarth, T., Grade, M., König, A. O., Ghadimi, M., & Gaedcke, J. (2023). Impact of Portal Vein Resection (PVR) in Patients Who Underwent Curative Intended Pancreatic Head Resection. Biomedicines, 11(11), 3025. https://doi.org/10.3390/biomedicines11113025