Circular RNAs: A New Approach to Multiple Sclerosis
Abstract
:1. General Considerations on Multiple Sclerosis
2. Non-Coding RNAs
2.1. Circular RNAs
2.1.1. circRNAs Identification Tools
2.1.2. CircRNA Biogenesis
2.1.3. circRNAs Functions
3. Multiple Sclerosis and circRNAs
3.1. Epigenetic Mechanisms
3.2. circRNAs Biomarkers in MS
3.3. Extracellular Vesicles and circRNAs
3.4. circRNAs Genetic Variation in MS
3.5. circRNAs and B-Cell Function
3.6. Roles of circRNAs in MS
3.6.1. hsa_circ_0106803 of GSDMB Gene
3.6.2. circ_HECW2 and the Dysfunction of the Blood–Brain Barrier
3.6.3. hsa_circ_0106803 Modulates the Expression of ASIC1a mRNA
3.6.4. circINPP4B Regulates Th17 Cell Differentiation
3.6.5. hsa_circRNA_101145 and hsa_circRNA_001896 in Patients with Relapse-Remitting MS
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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circRNA | Gene | References |
---|---|---|
hsa_circ_0106803 | GSDMB | Cardamone et al. [127] |
hsa_circ_0007990 | PGAP3 | Cardamone et al. [75] |
circ_0005402 circ_0035560 | ANXA2 | Iparraguirre et al. [83] |
hsa_circ_0043813 | STAT3 | Paraboschi et al. [101] |
hsa_circRNA_101348 hsa_circRNA_102611 hsa_circRNA_104361 | AK2 IKZF3 CBX5 | Zurawska et al. [114] |
circ_HECW2 | HECW2 | Yang et al. [125] Dong et al. [126] |
hsa_circ_0106803 | ASIC1a | Cardamone et al. [127] Xia et al. [89] |
circ_3998 | INPP4B | Han et al. [35] |
hsa_circRNA_101145 hsa_circRNA_001896 | NOS1 NOPCHAP1 DSE | Mycko et al. [144] |
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Sciaccotta, R.; Murdaca, G.; Caserta, S.; Rizzo, V.; Gangemi, S.; Allegra, A. Circular RNAs: A New Approach to Multiple Sclerosis. Biomedicines 2023, 11, 2883. https://doi.org/10.3390/biomedicines11112883
Sciaccotta R, Murdaca G, Caserta S, Rizzo V, Gangemi S, Allegra A. Circular RNAs: A New Approach to Multiple Sclerosis. Biomedicines. 2023; 11(11):2883. https://doi.org/10.3390/biomedicines11112883
Chicago/Turabian StyleSciaccotta, Raffaele, Giuseppe Murdaca, Santino Caserta, Vincenzo Rizzo, Sebastiano Gangemi, and Alessandro Allegra. 2023. "Circular RNAs: A New Approach to Multiple Sclerosis" Biomedicines 11, no. 11: 2883. https://doi.org/10.3390/biomedicines11112883