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Article

Sex-Related Differences in Voluntary Alcohol Intake and mRNA Coding for Synucleins in the Brain of Adult Rats Prenatally Exposed to Alcohol

1
V.P. Serbsky Federal Medical Research Centre for Psychiatry and Narcology, 119034 Moscow, Russia
2
Institute of Physiologically Active Compounds RAS, 142432 Chernogolovka, Russia
3
Belgorod State National Research University, 308015 Belgorod, Russia
4
Lomonosov Moscow State University, 119991 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Laura Orio
Biomedicines 2022, 10(9), 2163; https://doi.org/10.3390/biomedicines10092163
Received: 2 July 2022 / Revised: 17 August 2022 / Accepted: 29 August 2022 / Published: 2 September 2022
Maternal alcohol consumption is one of the strong predictive factors of alcohol use and consequent abuse; however, investigations of sex differences in response to prenatal alcohol exposure (PAE) are limited. Here we compared the effects of PAE throughout gestation on alcohol preference, state anxiety and mRNA expression of presynaptic proteins α-, β- and γ-synucleins in the brain of adult (PND60) male and female Wistar rats. Total RNA was isolated from the hippocampus, midbrain and hypothalamus and mRNA levels were assessed with quantitative RT-PCR. Compared with naïve males, naïve female rats consumed more alcohol in “free choice” paradigm (10% ethanol vs. water). At the same time, PAE produced significant increase in alcohol consumption and preference in males but not in females compared to male and female naïve groups, correspondingly. We found significantly lower α-synuclein mRNA levels in the hippocampus and midbrain of females compared to males and significant decrease in α-synuclein mRNA in these brain areas in PAE males, but not in females compared to the same sex controls. These findings indicate that the impact of PAE on transcriptional regulation of synucleins may be sex-dependent, and in males’ disruption in α-synuclein mRNA expression may contribute to increased vulnerability to alcohol-associated behavior. View Full-Text
Keywords: prenatal alcohol exposure; synucleins; alcohol consumption; free-choice; hippocampus; midbrain; mRNA expression; α-synuclein; rats prenatal alcohol exposure; synucleins; alcohol consumption; free-choice; hippocampus; midbrain; mRNA expression; α-synuclein; rats
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MDPI and ACS Style

Kokhan, V.S.; Chaprov, K.; Ninkina, N.N.; Anokhin, P.K.; Pakhlova, E.P.; Sarycheva, N.Y.; Shamakina, I.Y. Sex-Related Differences in Voluntary Alcohol Intake and mRNA Coding for Synucleins in the Brain of Adult Rats Prenatally Exposed to Alcohol. Biomedicines 2022, 10, 2163. https://doi.org/10.3390/biomedicines10092163

AMA Style

Kokhan VS, Chaprov K, Ninkina NN, Anokhin PK, Pakhlova EP, Sarycheva NY, Shamakina IY. Sex-Related Differences in Voluntary Alcohol Intake and mRNA Coding for Synucleins in the Brain of Adult Rats Prenatally Exposed to Alcohol. Biomedicines. 2022; 10(9):2163. https://doi.org/10.3390/biomedicines10092163

Chicago/Turabian Style

Kokhan, Viktor S., Kirill Chaprov, Natalia N. Ninkina, Petr K. Anokhin, Ekaterina P. Pakhlova, Natalia Y. Sarycheva, and Inna Y. Shamakina. 2022. "Sex-Related Differences in Voluntary Alcohol Intake and mRNA Coding for Synucleins in the Brain of Adult Rats Prenatally Exposed to Alcohol" Biomedicines 10, no. 9: 2163. https://doi.org/10.3390/biomedicines10092163

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