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Progress on Genetic Basis of Primary Aldosteronism
 
 
Review
Peer-Review Record

Genetic Alterations in Benign Adrenal Tumors

Biomedicines 2022, 10(5), 1041; https://doi.org/10.3390/biomedicines10051041
by Georgia Pitsava 1,2,* and Constantine A. Stratakis 2,3,4
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Biomedicines 2022, 10(5), 1041; https://doi.org/10.3390/biomedicines10051041
Submission received: 7 March 2022 / Revised: 20 April 2022 / Accepted: 21 April 2022 / Published: 30 April 2022
(This article belongs to the Special Issue Pathogenesis and Treatment of Adrenal Tumors)

Round 1

Reviewer 1 Report

The authors provide a very nice and comprehensive view on the genetics in benign adrenal tumors. Especially the section on cortisol producing tumors is very detailed. In comparison to that section of the manuscript, the second part on primary aldosteronism seems a little less comprehensive. Therefore, I would suggest to go a little bit more into detail especially regarding classical APAs and respective mutations, maybe add an additional figure on the altered channel/pump functions. Furthermore, I feel, that a section on non-functioning adenomas is lacking.

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

This minireview describing the genetic aberrations in benign tumors is thoroughly referenced and makes a significant contribution to endocrinology. 

The topic is original and encompasses the genetic causes of adrenal tumors seen in the various subtypes of primary aldosteronism and Cushing syndrome. 
The genetic landscape of the various types of adrenal adenomas has been elucidated in the past decade. The current manuscript highlights the genetic basis of adrenal adenomas that are seen in primary aldosteronism and Cushing syndrome. The research is well-referenced and interesting. 

Author Response

We sincerely thank Reviewer 2 for his/her nice comments.

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