Transcranial Magnetic Stimulation Following a Paired Associative Stimulation Protocol Based on a Video Game Neuromodulates Cortical Excitability and Motor Behavior
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. Transcranial Magnetic Stimulation
2.3. Electromyography (EMG) Recordings
2.4. Movement-Related Dynamic Task (MRDT)
2.5. Experimental Design
2.6. Statistical Analysis
3. Results
3.1. Behavioral Results
3.2. Cortico-Spinal Excitability
3.3. Correlation between RTs and MEPs
4. Discussion
4.1. PAS Effects on Behavioral Indices
4.1.1. RT Index
4.1.2. TE and the Number of Collected and Avoided Items
4.2. PAS Effects on MEPs
4.2.1. APB Muscle
4.2.2. ADM Muscle
4.3. Why Are the MEP Effects Different Depending on the TMS Pulse Intensity?
4.4. Methodological Considerations and Limitations of the Study
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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San Agustín, A.; Asín-Prieto, G.; Moreno, J.C.; Oliviero, A.; Pons, J.L. Transcranial Magnetic Stimulation Following a Paired Associative Stimulation Protocol Based on a Video Game Neuromodulates Cortical Excitability and Motor Behavior. Biomedicines 2022, 10, 2632. https://doi.org/10.3390/biomedicines10102632
San Agustín A, Asín-Prieto G, Moreno JC, Oliviero A, Pons JL. Transcranial Magnetic Stimulation Following a Paired Associative Stimulation Protocol Based on a Video Game Neuromodulates Cortical Excitability and Motor Behavior. Biomedicines. 2022; 10(10):2632. https://doi.org/10.3390/biomedicines10102632
Chicago/Turabian StyleSan Agustín, Arantzazu, Guillermo Asín-Prieto, Juan C. Moreno, Antonio Oliviero, and José L. Pons. 2022. "Transcranial Magnetic Stimulation Following a Paired Associative Stimulation Protocol Based on a Video Game Neuromodulates Cortical Excitability and Motor Behavior" Biomedicines 10, no. 10: 2632. https://doi.org/10.3390/biomedicines10102632