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Chemosensors 2017, 5(4), 28; https://doi.org/10.3390/chemosensors5040028

Possibilities and Challenges for Quantitative Optical Sensing of Hydrogen Peroxide

1
Marine Biological Section, Department of Biology, University of Copenhagen, 3000 Helsingør, Denmark
2
Climate Change Cluster, University of Technology Sydney, Ultimo, NSW 2007, Australia
*
Author to whom correspondence should be addressed.
Received: 11 September 2017 / Revised: 3 October 2017 / Accepted: 5 October 2017 / Published: 11 October 2017
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Abstract

Hydrogen peroxide (H2O2) plays a key role in many biological processes spanning from coral bleaching, over cell signaling to aging. However, exact quantitative assessments of concentrations and dynamics of H2O2 remain challenging due to methodological limitations—especially at very low (sub μM) concentrations. Most published optical detection schemes for H2O2 suffer from irreversibility, cross sensitivity to other analytes such as other reactive oxygen species (ROS) or pH, instability, temperature dependency or limitation to a specific medium. We review optical detection schemes for H2O2, compare their specific advantages and disadvantages, and discuss current challenges and new approaches for quantitative optical H2O2 detection, with a special focus on luminescence-based measurements. We also review published concentration ranges for H2O2 in natural habitats, and physiological concentrations in different biological samples to provide guidelines for future experiments and sensor development in biomedical and environmental science. View Full-Text
Keywords: hydrogen peroxide; H2O2; optical sensor; optical probes; reactive oxygen species (ROS); fluorescence; chemiluminescence hydrogen peroxide; H2O2; optical sensor; optical probes; reactive oxygen species (ROS); fluorescence; chemiluminescence
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Moßhammer, M.; Kühl, M.; Koren, K. Possibilities and Challenges for Quantitative Optical Sensing of Hydrogen Peroxide. Chemosensors 2017, 5, 28.

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