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Musculoskeletal Changes in Hemophilia Patients Subsequent to COVID−19 Lockdown

Department of Physiotherapy, University of Murcia, 30100 Murcia, Spain
Royal Victoria Eugenia Foundation, 28029 Madrid, Spain
Tú. Bienestar 360°, Physiotherapy and Medical Center, 30730 San Javier-Murcia, Spain
Department of Physiotherapy, Catholic University San Antonio-UCAM, 30107 Murcia, Spain
Department of Physiotherapy, European University of Madrid, 28670 Madrid, Spain
Author to whom correspondence should be addressed.
Academic Editors: Gianluigi Pasta and Matteo Di Minno
Healthcare 2021, 9(6), 702;
Received: 3 May 2021 / Revised: 4 June 2021 / Accepted: 6 June 2021 / Published: 9 June 2021
(This article belongs to the Special Issue Musculoskeletal Pain Care and Management in Rare Diseases)
(1) Background. The lockdown period due to the COVID−19 pandemic has drastically decreased levels of physical activity in the population. Hemophilia is characterized by hemarthrosis that leads to chronic, progressive and degenerative joint deterioration. (2) Methods. This observational study recruited 27 patients with hemophilia and arthropathy. Knee, ankle and elbow joints were assessed. The frequency of clinical hemarthrosis, pain intensity, pressure pain threshold, and joint ROM were evaluated. (3) Results. Following lockdown, a significant deterioration of joint condition, perceived joint pain and range of motion was noted in all joints. There were no changes in the frequency of knee hemarthrosis, while the frequency of ankle hemarthrosis significantly reduced. However, the frequency of elbow hemarthrosis increased. Depending on the degree of hemophilia severity, there were changes in pressure pain threshold in the elbow and in pain intensity and range of motion of the ankle joint. According to the type of treatment, i.e., prophylaxis vs. on-demand treatment, there were differences in the joint condition in elbows and the plantar flexion movement of the ankle. There were no differences in the knee joint based on the severity of the disease, the type of treatment or the development of inhibitors (4). Conclusions. Because of the COVID−19 lockdown, the musculoskeletal status of patients with hemophilia deteriorated. Joint condition, perceived pain, and range of motion were significantly affected. The frequency of clinical hemarthrosis did not increase during this period. A more active therapeutic model could prevent rapid deterioration in patients with hemophilic arthropathy during prolonged sedentary periods. View Full-Text
Keywords: hemophilia; COVID−19; joint disease; musculoskeletal pain; physiotherapy modalities hemophilia; COVID−19; joint disease; musculoskeletal pain; physiotherapy modalities
MDPI and ACS Style

Cuesta-Barriuso, R.; Meroño-Gallut, J.; Pérez-Llanes, R.; Ucero-Lozano, R. Musculoskeletal Changes in Hemophilia Patients Subsequent to COVID−19 Lockdown. Healthcare 2021, 9, 702.

AMA Style

Cuesta-Barriuso R, Meroño-Gallut J, Pérez-Llanes R, Ucero-Lozano R. Musculoskeletal Changes in Hemophilia Patients Subsequent to COVID−19 Lockdown. Healthcare. 2021; 9(6):702.

Chicago/Turabian Style

Cuesta-Barriuso, Rubén, Javier Meroño-Gallut, Raúl Pérez-Llanes, and Roberto Ucero-Lozano. 2021. "Musculoskeletal Changes in Hemophilia Patients Subsequent to COVID−19 Lockdown" Healthcare 9, no. 6: 702.

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