Physical Therapy Is an Underutilized Health Resource for Children with Cancer: A Retrospective Study Identifies Facilitators for Improvement
by
Victoria Marchese
1, 
Lauren Savage
1,
Kai Sun
1,
Madhurika Situt
1,
Teresa York
2 and
Rachel Reoli
1,* 1
Department of Physical Therapy and Rehabilitation Sciences, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
2
Pediatric Hematology/Oncology Clinic, University of Maryland, Baltimore, MD 21201, USA
*
Author to whom correspondence should be addressed.
Healthcare 2026, 14(1), 20; https://doi.org/10.3390/healthcare14010020 (registering DOI)
Submission received: 5 November 2025
/
Revised: 10 December 2025
/
Accepted: 18 December 2025
/
Published: 21 December 2025
(This article belongs to the Special Issue Role of Physiotherapy in Promoting Physical Activity and Well-Being)
Abstract
Purpose: Childhood cancers are the cause of treatment-associated morbidities, impairing functional mobility, participation and quality of life. Physical therapy is known to have a positive impact on health and well-being. Unfortunately, physical therapy is not utilized to its capacity. Thus, the aim of our study is to assess variables that facilitate utilization of physical therapy for children with oncological diagnoses across the continuum of care. Methods: A retrospective observational study of medical records was completed for children who received care at a large medical system. Descriptive statistics and multiple logistic regressions were performed. Results: Record review identified 16,975 episodes of care for 693 children. Of the 16,975, 240 included a referral to physical therapy. Of the 240, 178 used physical therapy. Presence of pain (odds ratio (OR) 20.026, p < 0.001), and being prescribed Ifosfamide or Daunorubicin (OR 28.213, p < 0.001; OR 15.439, p < 0.001, respectively) increased the likelihood of using physical therapy. Conclusions: We confirmed that physical therapy is underutilized for children with oncological diagnoses. However, clinical and socioeconomic variables were identified that facilitate use of physical therapy.
Keywords:
physical therapy; pediatrics; oncology; utilization; rehabilitation; vincristine; ifosfamide1. Introduction
Cancers are the leading cause of death by disease in children and adolescents both in the United States and globally, and are a primary source of treatment-associated morbidities [1,2]. Five-year survival rates have improved significantly for pediatric cancers in the last few decades from 63% in the 1970s to 83% in the 2000s [3]. The most common pediatric cancers are leukemia, central nervous system (CNS) tumors, lymphomas, and sarcomas [4,5,6]. Increases in survival rates are largely attributable to advancements in treatments including surgery, radiation, chemotherapy, targeted therapy and immunotherapy [7]. Despite the decrease in overall mortality, functional outcomes for childhood cancer differ depending on the type of malignancy, presence of metastases, age of clinical onset, acquisition of developmental milestones, anatomical site, stage of the disease, and presence or absence of somatic mutations [8]. Physical therapy has been shown to improve functional outcomes [9,10,11]; however, it is an underutilized resource [12] despite its cost benefit [13].
There is increasing evidence that factors in the environment where children live, play and grow may impact survival and quality of life for children with cancer [1,14,15]. Gilchrist et al. 2023 reported “…rehabilitation services are being increasingly provided to patients with ALL [Acute Lymphoblastic Leukemia] at a relatively low cost per patient, yet geographic variability in care utilization is evident” [13]. The area of deprivation index is a scale that ranks the conditions of neighborhoods, with a score of one reflecting the least disadvantaged groups and a score of ten representing the most disadvantaged [16,17]. Higher ADI is correlated with an increased risk of multimorbidity and indicates that neighborhood context contributes to health outcomes [18]. Furthermore, lack of health insurance or access to health services is associated with reduced care throughout the cancer treatment process including prevention, screening, and symptom management [19]. Yet it is known that access to healthcare increases survivorship [8].
While medical interventions result in higher survivorship across childhood cancer, the treatments can also lead to functional impairments. In addition to physical therapy, treatments for pediatric cancer patients include chemotherapy, radiation, targeted therapy, immunotherapy, and surgical removal, all of which have side effects that may impact mobility [20]. Long-term survivors of childhood cancers who experience persistent chronic fatigue have more depressive symptoms, anxiety, pain, and insomnia. They also engage in less physical activity and have an impaired ability to complete functional tasks [21,22]. Additionally, cardiovascular disease and neurologic complications often arise prematurely in pediatric cancer survivors because of the long-term effects of chemotherapy and radiation [23]. Specifically, chemotherapy is known to produce peripheral neuropathy, which can cause side effects such as numbness and weakness that impact functional mobility [24]. Approximately 83% of childhood ALL survivors experience neurological symptoms [25,26]. Common lasting side effects prevalent in survivors of central nervous system tumors include pain, seizures, and motor and sensory loss [27]. While loss of physical function is prevalent across all cancer types, musculoskeletal sarcoma often requires both pharmacological and surgical treatment [28]. These procedures may result in impairments in muscle properties including muscle strength and size, and neuromuscular activation. These functional deficits can limit a patient’s participation in school, work, and recreation [29,30]. It is known that physical therapy improves these multisystem impairments and increases functional mobility and quality of life for individuals with pediatric cancers [7,9,11,31,32,33,34,35]; thus, it is important to understand facilitators and barriers to physical therapy access and utilization.
Despite the broad range of functional impairments associated with oncology treatments, there is a lack of consistency in referring and providing rehabilitation services for childhood cancer survivors. Current guidelines suggest referral to physical therapy for comorbidity management [36], whereas others suggest a more frequent rehabilitation schedule for prevention [37]. It is well documented in the literature that physical therapy during and after treatment is feasible [33], effective [9,10], and can improve functional mobility for these individuals. Despite these findings, Rodwin et al. reported that only 27.2% of pediatric ALL patients overall and 58.9% of those with neuromuscular conditions received inpatient physical therapy within a year of first being admitted for cancer treatment [12]. The variables that impact referral and use of physical therapy services for pediatric oncology patients undergoing either active treatment or long-duration survivorship are largely unknown. Studies have found that factors including higher educational level, employment, and urban environment were correlated with a higher likelihood of using physical therapy [38]. However, pediatric patients with cancer face different challenges than the general population. Therefore, there is a critical gap in knowledge regarding the underlying factors affecting the referral and use of physical therapy among patients with childhood cancers. Knowledge of these variables could positively impact access to care. Thus, the aim of our study is to assess facilitators to utilization of physical therapy for children with oncological diagnoses across the continuum of care. Identification of these variables may foster precision-based rehabilitation to ultimately improve quality of life.
2. Materials and Methods
Study Design
A retrospective observational study design was utilized. Following Institutional Review Board (IRB) approval, HP-00111699, electronic medical records were retrospectively accessed for children who received care for oncological diagnoses, from twenty medical center sites, within a single healthcare system, across the continuum of care (acute care to outpatient settings). Electronic medical records were retrieved in one timepoint by an investigator from the University’s Institute for Clinical and Translational Research using medical record variables defined by the primary investigator. Medical record variables included age, race, gender, height, weight, insurance, area of deprivation index, admission type, diagnosis (all codes for cancer), pain, physical therapy referral orders (including provider notes), physical therapy evaluation, medications (ifosfamide, daunorubicin, vincristine, doxorubicin, vinblastine, carboplatin, cisplatin, epirubicin, idarubicin, mitoxantrone, valrubicin). Ages were divided into five groups based on years of age (0–3, 4–6, 7–10, 11–15, 16–18). Area Deprivation Index (ADI) followed the traditional ADI numerical scale of one (least disadvantaged) to ten (most disadvantaged). All ADIs were included to better understand the population receiving medical care [17]. Once collected, electronic medical record data was stored and analyzed according to the University’s IRB protocol. The Strengthening the Reporting of Observational Studies in Epidemiology guidelines were followed. Participants were included if they had a diagnosis of pediatric cancer and received medical care from 1 January 2016 to 1 July 2024. Ages birth to eighteen were included. Per IRB protocol, the study was deemed exempt and consent waived.
Using the results of prior literature that identified variables associated with functional outcomes [39], it was identified that a sample size of 650 participants was required for a power of 0.80. Characteristic factors of subjects including age in groups, ADI in groups, insurance, different medication uses, pain, and admission (inpatient vs. outpatient), were reported as frequency. Chi-square tests were used for the comparisons. The multiple logistic regression models with random effects for individuals used to account for the non-independence of multiple episodes from the same patient (PROC GLIMMIX Procedure) were used to examine the possible impacts of characteristics of subjects to overall referral to physical therapy and overall physical evaluation, respectively. Effects were shown with odds ratios. Episodes of medical care were used for each model. Episodes of medical care included any admission to an inpatient or outpatient service; thus, for physical therapy, one referral would be necessary per episode of medical care. Given the multiple episodes of medical care for several patients, multiple logistic regression mixed models were used to address impacts of characteristics of subjects to referral and use of physical therapy to account for the non-independence of multiple episodes from the same patient. The clustering was addressed by including a random effect for individual. The variables included in the models are age, ADI, insurance, pain or not, inpatient location or not, Ifosamide use, Daunorubicin use, Vincristine use, and Doxorubicine use. Per the significant level and the clinical importance, the covariates were selected. The Hosmer–Lemeshow-type test was conducted to check the goodness of fit of the model. No missing data handling was conducted; missing data was automatically excluded from the analysis and did not substantially reduce sample size.
All analyses were performed using Statistical Analysis System (SAS) (v. 9.4, SAS Institute, Inc., Cary, NC, USA) with a significance level of 0.05.
3. Results
3.1. Descriptive Characteristics
Retrospective data analysis of medical records identified 16,975 episodes of medical care from 1 January 2016 and 31 March 2024, for 693 children with pediatric oncological diagnoses, which formed the denominators for episode-level analysis of physical therapy referral and use. Out of the 16,975 episodes of medical care, 240 episodes included a referral to physical therapy. Blood cancers accounted for 177 episodes; 15 were cancers of the nervous system, 32 were sarcomas, and 16 episodes were undefined or other. Of the 240 episodes that received referrals to physical therapy, 178 episodes used physical therapy services.
There was a significant difference in physical therapy referrals based on age (p = 0.05), ADI state rank (p < 0.001), insurance (p < 0.001), pain (p ≤ 0.001), medications (Vincristine (p < 0.001), Ifosfamide (p = 0.001), Daunorubicin (p < 0.001), Doxorubicin (p = 0.02), Idarubicin (p < 0.001)), and location (acute care versus outpatient) (p ≤ 0.001). Descriptive variables that were significant for children who used physical therapy services included ADI state rank (p < 0.001), insurance (p < 0.001), pain (p < 0.001), medications (Vincristine, Cisplatin, Ifosfamide, Daunorubicin, Doxorubicin, Idarubicin, and Mitoxantorone all (p < 0.001)) and location (acute care versus outpatient) (p ≤ 0.001). See Table 1 and Table 2.
3.2. Logistic Regression
Logistic regression found seven variables that were barriers to referral to physical therapy and four variables that facilitate d physical therapy. Barriers to physical therapy referral included being uninsured (OR 0.402, CI 0.198–0.814, p = 0.011), least disadvantaged ADI ranks (ADI 2 OR 0.159, CI 0.052–0.481, p = 0.001; ADI 3 OR 0.361, CI 0.143–0.915, p = 0.032; ADI 4 OR 0.240, CI 0.075–0.767, p = 0.016), and most disadvantaged ADI ranks (ADI 8 OR 0.363, CI 0.161–0.817, p = 0.014; ADI 9 OR 0.303, CI 0.121–0.755, p = 0.01; ADI 10 OR 0.309, CI 0.132–0.723, p = 0.007). Facilitators to physical therapy referral included presence of pain (OR 2.327, CI 1.592–3.401, p < 0.0001), being in the acute care setting (OR 1.792, CI 1.017–3.158, p = 0.044), and the medications Ifosfamide and Vincristine (OR 4.464, CI 1.433–13.9, p = 0.01; OR 1.69, CI 1.202–2.377, p = 0.003, respectively). See Table 3 for variables associated with referral of physical therapy.
Logistic regression identified three variables that impacted use of physical therapy: insurance, pain, and medication. Lack of insurance was a barrier to physical therapy use (uninsured, OR 0.06, CI 0.007–0.490, p = 0.009). Presence of pain increased physical therapy use (OR 20.026, CI 13.665–29.349, p ≤ 0.0001). Likewise, the medications Ifosfamide and Daunorubicin facilitated physical therapy use (OR 28.213, CI 12.031–66.161; OR 15.439, CI 5.454–43.705, respectively). See Table 4 for variables associated with use of physical therapy. The wide confidence intervals for Ifosomide and pain (as a predictor of physical therapy use) were due to very few occurrences of referral or use in those categories, as shown in Table 1 and Table 2. The Hosmer–Lemeshow-type test was conducted to check the goodness of fit of the model, with a p-value of 0.34, indicating a good fit.
4. Discussion
As survival rates improve, childhood cancers have become the leading cause of treatment-associated morbidities in the United States [1,2]. Children with oncological diagnoses experience impairments in multiple body systems, from both the cancer as well as from the life-saving medical interventions [20,21,22,23,24,25,26,27,28,29]. These impairments impact functional mobility, participation and quality of life [25]. Physical therapy is known to positively impact impairments and reduce secondary complications throughout the lifespan [7,9,11,30,31,32,33,34]. Thus, the aim of our study was to assess facilitators to access and use of physical therapy for children with cancer. We identified that for children with oncological diagnoses 240 of the 16,975 episodes of medical care had a referral to physical therapy. Additionally, of the 240 episodes that did receive a physical therapy referral, 178 episodes had associated physical therapy treatments. The American Physical Therapy (APTA) Health Promotion and Wellness Network states “the purpose…is to facilitate the profession’s role in transforming society and physical therapist practice by connecting people and knowledge to develop and disseminate best practices in prevention, health promotion, and wellness for all individuals and populations” [40]. In support of the APTA, our study identified both facilitators and barriers to physical therapy referrals and use for children with oncological diagnoses. Implementation of these variables into clinical settings may aid in the use of physical therapy services.
One of these variables, ADI, was found to be a barrier to referral to physical therapy. We identified ADI 5 to be the most common ADI served by the medical system. Interestingly, children housed in ADIs that were ranked as least disadvantaged (ADIs of two, three, and four) and children that were ranked as the most disadvantaged (ADIs eight, nine, and ten) had a lower likelihood of being referred to physical therapy services as compared to those with ADIs on the very least disadvantaged end (ADI one) or in the middle range (ADIs six and seven). As aforementioned, it is known that the general population with disadvantaged ADIs has reduced access to physical therapy [31]. Additionally, the results of our study collaborate with the findings by Gilchrist et al. that rehabilitation services are not equally provided across geographic regions for children with oncological diagnoses [13]. However, surprisingly, we found that children living in some of the least disadvantaged ADIs (ADI two, three and four) were also not likely to be referred to physical therapy services. Given this finding, we hypothesize that providers may assume children with lower ranking ADIs may already have access to home, community and school-based services other than physical therapy, such as a community recreational center or gymnasium, lowering the perceived need for physical therapy; however, our findings would lead to encouraging clinicians to communicate with patients regardless of ADI when physical therapy is indicated, and not assume that resources are or are not available.
A second variable, which may be related to ADI, that our study identified as significant to receiving physical therapy, is insurance. Being uninsured was a barrier to both referral and use of physical therapy. It is known that being uninsured or having gaps in insurance negatively impacts cancer care and survival rates [14]. Therefore, it is imperative that healthcare providers incorporate members of the multidisciplinary team, e.g., social work, to assist with opportunities for children and families to receive financial assistance for medical care, including physical therapy services. By sharing resources and opportunities for insurance coverage, patients may be more likely to be referred to and use physical therapy to remediate primary impairments and prevent secondary complications.
Unlike ADI and insurance, the presence of pain was a facilitator to referral and use of physical therapy. Our findings align with the APTA “Choose Physical Therapy” initiative which states “physical therapists are movement experts who treat pain and improve quality of life through hands-on care, patient education, and prescribed movement. They help people manage or eliminate pain and reduce the need for surgery and pain medications, such as opioids. By increasing physical activity you can reduce your risk of developing many chronic diseases” [40]. Our results are similar to other findings that support the use of PT as part of a multidisciplinary team for pain management in children with oncological diagnoses [41] and show a positive implementation of the APTA initiative with increased referral and use of physical therapy for children with pediatric oncology diagnoses and pain.
As children with pediatric cancers are living longer due to medical interventions and pharmacological treatments [3], short and long-term side effects, in addition to pain, may also impact functional mobility and quality of life. Thus, we examined the impact of medications on referral and use of physical therapy [42]. We found that being prescribed the medications Ifosfamide and Vincristine increased referrals to physical therapy and Ifosfamide and Daunorubicin facilitated use of physical therapy services. The increase in referrals and use of physical therapy with these medications is in agreement with the Children’s Oncology Group’s Survivorship Guidelines, which state “physical therapy referral for patients with symptomatic neuropathy… for non-pharmacologic pain management, range of motion, strengthening, stretching, functional mobility” [43]. Additionally, our findings align with Tanner et al.’s systematic review which reported that chemotherapy-induced peripheral neuropathy impacts physical function and quality of life for survivors of pediatric cancers and thus, supportive care interventions should be implemented [24]. Therefore, the results of our study support that when medications with mobility impacting side effects such as fatigue and/or neuropathy are being prescribed, physical therapy is being offered and used by children with oncological diagnoses.
While our study identified facilitators and barriers for referral and use of physical therapy, it is important to note several limitations. Despite the large sample size, data was retrieved from a single medical system located in one state. Thus, ADI information may vary across regions and medical systems and does not capture physical therapy use outside of the medical system. Additionally, we opted to group all cancer types together to obtain a complete picture of use of physical therapy for patients with pediatric oncological diagnoses. However, different diagnoses may have functional impairments, treatments, side effects, and outcomes specific to the pathology [7,8]. Additionally, a limiting factor could be electronic medical record misclassification and the lack of standardized functional outcome measures to directly capture physical therapy needs. Thus, future research would benefit from assessing multiple hospital systems across ADIs, as well as analyzing specific types of childhood cancers.
5. Conclusions
Our study identified that while physical therapy is underutilized for children with oncological diagnoses across the continuum of care; children who did receive physical therapy had facilitatory variables that aligned with other healthcare governing bodies and guidelines. Thus, future studies would benefit from implementation of these findings into the clinical setting to assess if referrals and use of physical therapy increase with knowledge of these variables.
Author Contributions
Conceptualization, R.R., V.M. and T.Y.; methodology, R.R., M.S. and K.S.; software, K.S. and M.S.; validation, K.S., M.S. and R.R.; formal analysis, K.S. and R.R.; investigation, R.R. and M.S.; resources, V.M.; data curation, M.S. and K.S.; writing—original draft preparation, R.R., V.M. and L.S.; writing—review and editing, K.S., M.S., L.S. and T.Y.; visualization, R.R. and V.M.; supervision, R.R. and V.M.; project administration, V.M. All authors have read and agreed to the published version of the manuscript.
Funding
This research received no external funding.
Institutional Review Board Statement
The study was conducted in accordance with the Declaration of Helsinki and approved on 9 August 2024 by the University of Maryland School of Medicine’s Institutional Review Board HP-00111699 for studies involving humans.
Informed Consent Statement
Per the Institutional Review Board, the study is exempt and consent waived.
Data Availability Statement
The data sets presented in this article are not readily available given the nature of the data, protected patient health information.
Conflicts of Interest
The authors declare no conflicts of interest or funding to report.
Abbreviations
The following abbreviations are used in this manuscript:
| CNS | Central Nervous System |
| ALL | Acute Lymphoblastic Leukemia |
| ADI | Area of Deprivation Index |
| IRB | Institutional Review Board |
| OR | Odds Ratio |
| CI | Confidence Interval |
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Table 1.
Variables and Percentages of PT Referrals and Use.
| Variable | Overall | Referral | Referral: p-Value | Use | Use: p-Value |
|---|---|---|---|---|---|
| Age | 0.050 * | 0.110 | |||
| <3 | 2612 | 39 (1.493) | 27 (1.034) | ||
| 4–6 | 3354 | 35 (1.043) | 28 (0.845) | ||
| 7–10 | 3935 | 69 (1.753) | 32 (0.813) | ||
| 11–15 | 4469 | 53 (1.186) | 59 (1.320) | ||
| 16–18 | 2605 | 44 (1.689) | 32 (1.228) | ||
| Gender | 0.720 | 0.110 | |||
| Male | 9317 | 129 (1.385) | 87 (0.934) | ||
| Female | 7658 | 111 (1.449) | 91 (1.188) | ||
| ADI Group | <0.001 * | <0.001 * | |||
| 1 | 926 | 34 (3.671) | 7 (0.756) | ||
| 2 | 1405 | 7 (0.498) | 10 (0.712) | ||
| 3 | 1255 | 16 (1.275) | 8 (0.637) | ||
| 4 | 926 | 6 (0.648) | 3 (0.324) | ||
| 5 | 1478 | 39 (2.639) | 14 (0.947) | ||
| 6 | 1919 | 33 (1.719) | 18 (0.938) | ||
| 7 | 1268 | 27 (2.129) | 28 (2.208) | ||
| 8 | 2422 | 32 (1.321) | 22 (0.908) | ||
| 9 | 1688 | 19 (1.256) | 27 (1.599) | ||
| 10 | 2566 | 24 (0.935) | 27 (1.052) | ||
| Insurance | <0.001 * | <0.001 * | |||
| Medicaid | 6763 | 121 (1.789) | 116 (1.715) | ||
| Private | 4597 | 96 (2.088) | 61 (1.327) | ||
| Uninsured | 5615 | 23 (0.409) | 1 (0.018) | ||
| Pain | <0.001 * | <0.001 * | |||
| Not present | 6998 | 41 (0.586) | 6 (0.086) | ||
| Present | 9977 | 199 (1.995) | 172 (1.724) | ||
| Location | <0.001 * | <0.001 * | |||
| Outpatient | 6998 | 36 (0.514) | 6 (0.086) | ||
| Acute Care | 9977 | 204 (2.045) | 172 (1.724) |
Legend: Age (years); ADI: Area of Deprivation Index; () percentage; * significant at the level of a 0.05.
Table 2.
Medication and Percentages of PT Referrals and Use.
| Variable | Overall | Referral | Referral: p-Value | Use | Use: p-Value |
|---|---|---|---|---|---|
| Vincristine | <0.001 * | <0.001 * | |||
| No | 15,086 | 177 (1.173) | 140 (0.928) | ||
| Yes | 1889 | 63 (3.335) | 38 (2.011) | ||
| Cisplatin | 0.610 | <0.001 * | |||
| No | 16,932 | 239 (1.412) | 170 (1.004) | ||
| Yes | 43 | 1 (2.326) | 8 (18.60) | ||
| Ifosfamide | <0.001 * | <0.001 * | |||
| No | 16,914 | 236 (1.395) | 161 (0.952) | ||
| Yes | 61 | 4 (6.557) | 17 (27.869) | ||
| Daunorubicin | <0.001 * | <0.001 * | |||
| No | 16,924 | 236 (1.394) | 163 (0.963) | ||
| Yes | 51 | 4 (7.843) | 15 (29.412) | ||
| Doxorubicin | 0.020 * | <0.001 * | |||
| No | 16,626 | 230 (1.383) | 165 (0.992) | ||
| Yes | 349 | 10 (2.865) | 13 (3.725) | ||
| Idarubicin | <0.001 * | <0.001 * | |||
| No | 16,674 | 239 (1.433) | 177 (1.061) | ||
| Yes | 1 | 1 (100) | 1 (100) | ||
| Mitoxantrone | 0.811 | <0.001 * | |||
| No | 16,971 | 240 (1.414) | 174 (1.025) | ||
| Yes | 4 | 0 (0) | 4 (100) |
Legend: () percentage; * significant at the level of a 0.05.
Table 3.
Multiple Logistic Regression Mixed Models: Variables Associated with Referral to Physical Therapy.
Table 3.
Multiple Logistic Regression Mixed Models: Variables Associated with Referral to Physical Therapy.
| Variable | OR | CI Lower | CI Upper | p-Value |
|---|---|---|---|---|
| Gender male (female) | 0.903 | 0.580 | 1.407 | 0.652 |
| Insurance private (Medicaid) | 0.882 | 0.565 | 1.379 | 0.583 |
| Insurance uninsured (Medicaid) | 0.402 | 0.198 | 0.814 | 0.011 * |
| ADI rank 1 (5) | 0.668 | 0.247 | 1.809 | 0.427 |
| ADI rank 2 (5) | 0.159 | 0.052 | 0.481 | 0.001 * |
| ADI rank 3 (5) | 0.361 | 0.143 | 0.915 | 0.032 * |
| ADI rank 4 (5) | 0.240 | 0.075 | 0.767 | 0.016 * |
| ADI rank 6 (5) | 0.556 | 0.251 | 1.234 | 0.149 |
| ADI rank 7 (5) | 0.514 | 0.208 | 1.271 | 0.150 |
| ADI rank 8 (5) | 0.363 | 0.161 | 0.817 | 0.014 * |
| ADI rank 9 (5) | 0.303 | 0.121 | 0.755 | 0.010 * |
| ADI rank 10 (5) | 0.309 | 0.132 | 0.723 | 0.007 * |
| Pain yes (no) | 2.327 | 1.592 | 3.401 | <0.0001 * |
| Inpatient yes (no) | 1.792 | 1.017 | 3.158 | 0.044 * |
| Ifosfamide yes (no) | 4.464 | 1.433 | 13.900 | 0.010 * |
| Daunorubicin yes (no) | 1.330 | 0.420 | 4.206 | 0.628 |
| Vincristine yes (no) | 1.690 | 1.202 | 2.377 | 0.003 * |
| Doxorubicin yes (no) | 1.161 | 0.579 | 2.330 | 0.673 |
| Age 4–6 (0–3) | 0.697 | 0.393 | 1.237 | 0.218 |
| Age 7–10 (0–3) | 0.728 | 0.403 | 1.314 | 0.292 |
| Age 11–15 (0–3) | 0.698 | 0.380 | 1.283 | 0.247 |
| Age 16–18 (0–3) | 1.222 | 0.637 | 2.344 | 0.546 |
ADI: area of deprivation index; OR: odds ratio; CI: confidence interval; () indicates reference group; age in years. * significant at the level of a 0.05.
Table 4.
Multiple Logistic Regression Mixed Models: Variables Associated with Use of Physical Therapy.
Table 4.
Multiple Logistic Regression Mixed Models: Variables Associated with Use of Physical Therapy.
| Variable | OR | CI Lower | CI Upper | p-Value |
|---|---|---|---|---|
| Gender male (female) | 1.090 | 0.605 | 1.964 | 0.773 |
| Insurance private (Medicaid) | 0.611 | 0.327 | 1.142 | 0.123 |
| Insurance uninsured (Medicaid) | 0.058 | 0.007 | 0.490 | 0.009 * |
| ADI rank 1 (5) | 0.604 | 0.124 | 2.932 | 0.532 |
| ADI rank 2 (5) | 0.663 | 0.171 | 2.568 | 0.552 |
| ADI rank 3 (5) | 0.863 | 0.228 | 3.267 | 0.828 |
| ADI rank 4 (5) | 0.316 | 0.050 | 1.983 | 0.219 |
| ADI rank 6 (5) | 0.797 | 0.245 | 2.591 | 0.706 |
| ADI rank 7 (5) | 1.291 | 0.374 | 4.463 | 0.686 |
| ADI rank 8 (5) | 0.901 | 0.282 | 2.872 | 0.860 |
| ADI rank 9 (5) | 0.972 | 0.296 | 3.192 | 0.962 |
| ADI rank 10 (5) | 0.615 | 0.196 | 1.929 | 0.405 |
| Pain yes (no) | 20.026 | 13.665 | 29.349 | <0.0001 * |
| Inpatient yes (no) | 2.318 | 0.852 | 6.303 | 0.099 |
| Ifosfamide yes (no) | 28.213 | 12.031 | 66.161 | <0.0001 * |
| Daunorubicin yes (no) | 15.439 | 5.454 | 43.705 | <0.0001 * |
| Vincristine yes (no) | 0.976 | 0.576 | 1.655 | 0.929 |
| Doxorubicin yes (no) | 1.965 | 0.926 | 4.167 | 0.078 |
| Age 4–6 (0–3) | 1.274 | 0.582 | 2.792 | 0.545 |
| Age 7–10 (0–3) | 0.790 | 0.347 | 1.799 | 0.575 |
| Age 11–15 (0–3) | 0.736 | 0.323 | 1.676 | 0.466 |
| Age 16–18 (0–3) | 1.336 | 0.556 | 3.209 | 0.517 |
ADI: area of deprivation index; OR: odds ratio; CI: confidence interval; () indicates reference group; age in years. * significant at the level of a 0.05.
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MDPI and ACS Style
Marchese, V.; Savage, L.; Sun, K.; Situt, M.; York, T.; Reoli, R. Physical Therapy Is an Underutilized Health Resource for Children with Cancer: A Retrospective Study Identifies Facilitators for Improvement. Healthcare 2026, 14, 20. https://doi.org/10.3390/healthcare14010020
AMA Style
Marchese V, Savage L, Sun K, Situt M, York T, Reoli R. Physical Therapy Is an Underutilized Health Resource for Children with Cancer: A Retrospective Study Identifies Facilitators for Improvement. Healthcare. 2026; 14(1):20. https://doi.org/10.3390/healthcare14010020
Chicago/Turabian StyleMarchese, Victoria, Lauren Savage, Kai Sun, Madhurika Situt, Teresa York, and Rachel Reoli. 2026. "Physical Therapy Is an Underutilized Health Resource for Children with Cancer: A Retrospective Study Identifies Facilitators for Improvement" Healthcare 14, no. 1: 20. https://doi.org/10.3390/healthcare14010020
APA StyleMarchese, V., Savage, L., Sun, K., Situt, M., York, T., & Reoli, R. (2026). Physical Therapy Is an Underutilized Health Resource for Children with Cancer: A Retrospective Study Identifies Facilitators for Improvement. Healthcare, 14(1), 20. https://doi.org/10.3390/healthcare14010020
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