Effect of Family and Personal Medical History on Treatment Outcomes of Tyrosine Kinase Inhibitors (TKIs) in Non-Small Cell Lung Cancer (NSCLC)
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Definition of FPMH
2.3. Patient Population
2.4. Data Collection
2.5. Statistical Analysis
3. Results
3.1. Demographic and Clinical Characteristics
3.2. Tumor Characteristics, Staging, and Genetic Markers
3.3. Treatment Characteristics and Toxicity
3.4. Laboratory Findings and Medication Use
Correlation and Regression Analyses
3.5. Survival Analysis
3.6. Cox Regression Analysis
3.7. Predictors of FPMH (Logistic Regression)
4. Discussion
5. Conclusions
5.1. Summary
5.2. Recommendations
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristic | Without FPMH (n = 102) | With FPMH (n = 34) | p-Value |
---|---|---|---|
Gender (Female, %) | 54.9 (56/102) | 47.1 (16/34) | 0.552 |
Smoking Status (Never, %) | 62.7 (64/102) | 55.9 (19/34) | 0.612 |
Chronic Disease (Yes, %) | 15.7 (16/102) | 58.8 (20/34) | <0.001 |
ECOG ≥ 3 (Yes, %) | 1.0 (1/102) | 8.8 (3/34) | 0.048 |
Recurrence Post-Treatment (%) | 20.6 (21/102) | 41.2 (14/34) | 0.031 |
Age (Mean ± SD, years) | 62.73 ± 12.62 | 63.21 ± 12.01 | 0.846 |
Smoking Pack-Years (Mean ± SD) | 33.03 ± 21.11 | 39.06 ± 22.6 | 0.352 |
Overall Survival (Mean ± SD, months) | 29.05 ± 24.03 | 30.03 ± 29.39 | 0.846 |
Recurrence Duration (Mean ± SD, months) | 44.79 ± 36.85 | 51.94 ± 43.49 | 0.363 |
Characteristic | Without FPMH (n = 102) | With FPMH (n = 34) | p-Value |
---|---|---|---|
TNM Stage 1–2 (%) | 17.6 (18/102) | 23.5 (8/34) | 0.720 |
EGFR Mutation (Yes, %) | 83.3 (85/102) | 91.2 (31/34) | 0.402 |
ALK Mutation (Yes, %) | 12.7 (13/102) | 2.9 (1/34) | 0.192 |
ROS1 Mutation (Yes, %) | 2.9 (3/102) | 5.9 (2/34) | 0.792 |
Surgical Intervention (Yes, %) | 16.7 (17/102) | 29.4 (10/34) | 0.172 |
Non-Squamous Histology (%) | 97.1 (99/102) | 94.1 (32/34) | 0.792 |
PD-L1 Expression (Mean ± SD, %) | 2.35 ± 11.07 | 0.76 ± 4.29 | 0.562 |
Characteristic | Without FPMH (n = 102) | With FPMH (n = 34) | p-Value |
---|---|---|---|
Neoadjuvant Therapy (Yes, %) | 4.9 (5/102) | 5.9 (2/34) | 1.000 |
Adjuvant Chemotherapy (Yes, %) | 9.8 (10/102) | 14.7 (5/34) | 0.635 |
Metastatic Disease (Yes, %) | 90.2 (92/102) | 94.1 (32/34) | 0.727 |
Chemotherapy Adverse Effects (%) | 28.4 (29/102) | 50.0 (17/34) | 0.036 |
First-Line Response (CR, %) | 12.7 (13/102) | 14.7 (5/34) | 0.950 |
Metastatic Chemo Duration (Mean ± SD, months) | 9.82 ± 18.25 | 13.06 ± 17.65 | 0.522 |
Characteristic | Without FPMH (n = 102) | With FPMH (n = 34) | p-Value |
---|---|---|---|
CEA (Mean ± SD, ng/mL) | 80.36 ± 182.7 | 88.91 ± 238.74 | 0.782 |
AST (Mean ± SD, U/L) | 23.53 ± 20.79 | 22.53 ± 12.67 | 0.909 |
WBC (Mean ± SD, per μL) | 8327.42 ± 3707.12 | 8365.67 ± 3175.8 | 0.959 |
Hemoglobin (Mean ± SD, g/dL) | 12.21 ± 1.8 | 12.46 ± 1.88 | 0.517 |
PPI Use (Yes, %) | 17.6 (18/102) | 20.6 (7/34) | 1.000 |
Variable | Correlation Coefficient (r) | p-Value |
---|---|---|
Chronic Disease | 0.423 | <0.01 |
ECOG Performance Status | 0.201 | <0.05 |
Recurrence Post-Treatment | 0.204 | <0.05 |
Chemotherapy Side Effects | 0.197 | <0.05 |
Outcome | Odds Ratio (OR) | p-Value |
---|---|---|
Chronic Disease | 7.68 | <0.001 |
ECOG ≥ 3 | 9.77 | 0.052 |
Recurrence Post-Treatment | 2.70 | 0.020 |
Chemotherapy Side Effects | 2.52 | 0.023 |
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Surmeli, H.; Turkoglu, E.; Isik, D.; Kinikoglu, O.; Altintas, Y.E.; Ozkerim, U.; Oksuz, S.; Basoglu, T.; Odabas, H.; Turan, N. Effect of Family and Personal Medical History on Treatment Outcomes of Tyrosine Kinase Inhibitors (TKIs) in Non-Small Cell Lung Cancer (NSCLC). Healthcare 2025, 13, 1810. https://doi.org/10.3390/healthcare13151810
Surmeli H, Turkoglu E, Isik D, Kinikoglu O, Altintas YE, Ozkerim U, Oksuz S, Basoglu T, Odabas H, Turan N. Effect of Family and Personal Medical History on Treatment Outcomes of Tyrosine Kinase Inhibitors (TKIs) in Non-Small Cell Lung Cancer (NSCLC). Healthcare. 2025; 13(15):1810. https://doi.org/10.3390/healthcare13151810
Chicago/Turabian StyleSurmeli, Heves, Ezgi Turkoglu, Deniz Isik, Oguzcan Kinikoglu, Yunus Emre Altintas, Ugur Ozkerim, Sila Oksuz, Tugba Basoglu, Hatice Odabas, and Nedim Turan. 2025. "Effect of Family and Personal Medical History on Treatment Outcomes of Tyrosine Kinase Inhibitors (TKIs) in Non-Small Cell Lung Cancer (NSCLC)" Healthcare 13, no. 15: 1810. https://doi.org/10.3390/healthcare13151810
APA StyleSurmeli, H., Turkoglu, E., Isik, D., Kinikoglu, O., Altintas, Y. E., Ozkerim, U., Oksuz, S., Basoglu, T., Odabas, H., & Turan, N. (2025). Effect of Family and Personal Medical History on Treatment Outcomes of Tyrosine Kinase Inhibitors (TKIs) in Non-Small Cell Lung Cancer (NSCLC). Healthcare, 13(15), 1810. https://doi.org/10.3390/healthcare13151810