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Volume 10
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10.3390/healthcare10050763
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Review

Clinical Characteristics of ICI-Related Pancreatitis and Cholangitis Including Radiographic and Endoscopic Findings

by
Ryota Nakano
,
Hideyuki Shiomi
*,
Aoi Fujiwara
,
Kohei Yoshihara
,
Ryota Yoshioka
,
Shoki Kawata
,
Shogo Ota
,
Yukihisa Yuri
,
Tomoyuki Takashima
,
Nobuhiro Aizawa
,
Naoto Ikeda
,
Takashi Nishimura
,
Hirayuki Enomoto
and
Hiroko Iijima
Division of Gastroenterology and Hepato-Biliary-Pancreatology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Hyogo, Japan
*
Author to whom correspondence should be addressed.
Healthcare 2022, 10(5), 763; https://doi.org/10.3390/healthcare10050763
Submission received: 20 February 2022 / Revised: 6 April 2022 / Accepted: 16 April 2022 / Published: 20 April 2022
(This article belongs to the Special Issue The Advanced Role of Gastrointestinal Endoscopy for Inflammatory Disease)
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Abstract

The indications for immune checkpoint inhibitors (ICIs) have expanded to include carcinomas of various organs. However, as ICI therapy expands, the management of immune-related adverse events (irAEs) has become a problem. ICI-related pancreatitis and cholangitis are relatively rare irAEs. Although some patients with ICI-related pancreatitis and cholangitis are asymptomatic and do not require treatment, there have been reports of patients who did not respond to immunosuppressive therapy and died. Thus, the pathogenesis of ICI-related pancreatitis and cholangitis should be clarified immediately. Currently, the role of endoscopy in the diagnosis and treatment of inflammatory pancreatic and biliary duct diseases is becoming increasingly important. In this review, we summarize clinical characteristics as well as radiographic and endoscopic findings of ICI-related pancreatitis and cholangitis.
Keywords: ICI-related pancreatitis; ICI-related cholangitis; irAEs; EUS; ERCP ICI-related pancreatitis; ICI-related cholangitis; irAEs; EUS; ERCP

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MDPI and ACS Style

Nakano, R.; Shiomi, H.; Fujiwara, A.; Yoshihara, K.; Yoshioka, R.; Kawata, S.; Ota, S.; Yuri, Y.; Takashima, T.; Aizawa, N.; et al. Clinical Characteristics of ICI-Related Pancreatitis and Cholangitis Including Radiographic and Endoscopic Findings. Healthcare 2022, 10, 763. https://doi.org/10.3390/healthcare10050763

AMA Style

Nakano R, Shiomi H, Fujiwara A, Yoshihara K, Yoshioka R, Kawata S, Ota S, Yuri Y, Takashima T, Aizawa N, et al. Clinical Characteristics of ICI-Related Pancreatitis and Cholangitis Including Radiographic and Endoscopic Findings. Healthcare. 2022; 10(5):763. https://doi.org/10.3390/healthcare10050763

Chicago/Turabian Style

Nakano, Ryota, Hideyuki Shiomi, Aoi Fujiwara, Kohei Yoshihara, Ryota Yoshioka, Shoki Kawata, Shogo Ota, Yukihisa Yuri, Tomoyuki Takashima, Nobuhiro Aizawa, and et al. 2022. "Clinical Characteristics of ICI-Related Pancreatitis and Cholangitis Including Radiographic and Endoscopic Findings" Healthcare 10, no. 5: 763. https://doi.org/10.3390/healthcare10050763

APA Style

Nakano, R., Shiomi, H., Fujiwara, A., Yoshihara, K., Yoshioka, R., Kawata, S., Ota, S., Yuri, Y., Takashima, T., Aizawa, N., Ikeda, N., Nishimura, T., Enomoto, H., & Iijima, H. (2022). Clinical Characteristics of ICI-Related Pancreatitis and Cholangitis Including Radiographic and Endoscopic Findings. Healthcare, 10(5), 763. https://doi.org/10.3390/healthcare10050763

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