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The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant Activity

1
Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece
2
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University Thessaloniki, 54124 Thessaloniki, Greece
3
Department of Forests, Ministry of Agriculture, Natural Resources and Environment, Nicosia 1414, Cyprus
*
Author to whom correspondence should be addressed.
Received: 2 November 2017 / Revised: 15 December 2017 / Accepted: 20 December 2017 / Published: 27 December 2017
(This article belongs to the Special Issue Plant Flavonoids)
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Abstract

The phytochemical analysis of the polar extracts of Cedrus brevifolia needles yielded 20 compounds, namely from the methanol extract we isolated three flavonoids (13), one hydrolysable tannin (4), eleven phenolic derivatives (515) and one apocarotenoid (16), while from the methanol: water (5:1) extract we isolated four flavonoids (1720). Chemical structures of all isolated compounds were determined by 1D, 2D-NMR (1 Dimension, 2 Dimensions Nuclear Magnetic Resonance) and UV-Vis (Ultraviolet-Visible) spectroscopy. Furthermore, the antioxidant potentials and the anti-inflammatory activities of both crude extracts and isolates were evaluated through DPPH radical scavenging capability, linoleic acid lipid peroxidation inhibition, and soybean LOX inhibition assays. This is the first report on the chemical profile of C. brevifolia needles. Catechin was the main compound derived from the methanol extract. According to our results, 4-O-β-d-glucopyranyl trans-p-coumaric acid and taxifolin were the most active ingredients. View Full-Text
Keywords: C. brevifolia; flavonoids; catechin; simple phenols; apocarotenoids; bioactivity, antioxidant; reducing power; total antioxidant capacity; reactive oxygen species C. brevifolia; flavonoids; catechin; simple phenols; apocarotenoids; bioactivity, antioxidant; reducing power; total antioxidant capacity; reactive oxygen species
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Douros, A.; Hadjipavlou-Litina, D.; Nikolaou, K.; Skaltsa, H. The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant Activity. Plants 2018, 7, 1.

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