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Article

Rosa davurica Inhibited Allergic Mediators by Regulating Calcium and Histamine Signaling Pathways

by
Seojun Lim
1,†,
Sarang Oh
2,†,
Quynh T. N. Nguyen
1,
Myeongju Kim
1,
Shengdao Zheng
2,
Minzhe Fang
1 and
Tae-Hoo Yi
1,*
1
Graduate School of Biotechnology, Kyung Hee University, Yongin 17104, Republic of Korea
2
Snowwhitefactory Co., Ltd., 807 Nonhyeon-ro, Gangnam-gu, Seoul 06032, Republic of Korea
*
Author to whom correspondence should be addressed.
†
These authors equally contributed to this work.
Plants 2023, 12(7), 1572; https://doi.org/10.3390/plants12071572
Submission received: 13 March 2023 / Revised: 30 March 2023 / Accepted: 3 April 2023 / Published: 6 April 2023
(This article belongs to the Special Issue Chemical Profiling and Biological Activity of Plant Natural Compounds II)
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Abstract

Rosa davurica Pall. exhibits antioxidant, antiviral, and anti-inflammatory properties; however, its pharmacological mechanism in allergy is yet to be understood. This study confirmed the effects of R. davurica Pall. leaf extract (RLE) on allergy as a new promising material. To evaluate the therapeutic potential of RLE against allergy, we investigated the effects of RLE on the regulatory β-hexosaminidase, histamine, histidine decarboxylase (HDC), Ca2+ influx, nitric oxide (NO), and cytokines induced by lipopolysaccharide (LPS) and DNP-IgE/BSA in Raw 264.7 and RBL-2H3 cells. Furthermore, we examined the effects of RLE on the signaling pathways of mitogen-activated protein kinase (MAPK) and Ca2+ pathways. After stimulating Raw 264.7 cells with LPS, RLE reduced the release of inflammatory mediators, such as NO, cyclooxygenase (COX)-2, inducible nitric oxygen synthase (iNOS), interleukin (IL)-1β, -6, and tumor necrosis factor (TNF)-α. Also, RLE reduced the β-hexosaminidase, histamine, HDC, Ca2+ influx, Ca2+ pathways, and phosphorylation of MAPK in DNP-IgE/BSA-stimulated RBL-2H3 cells. Our studies indicated that RLE is a valuable ingredient for treating allergic diseases by regulating cytokine release from macrophages and mast cell degranulation. Consequently, these results suggested that RLE may serve as a possible alternative promising material for treating allergies.
Keywords: Rosa davurica; allergy; β-hexosaminidase; histamine; Ca2+ influx; histidine decarboxylase (HDC) Rosa davurica; allergy; β-hexosaminidase; histamine; Ca2+ influx; histidine decarboxylase (HDC)
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MDPI and ACS Style

Lim, S.; Oh, S.; Nguyen, Q.T.N.; Kim, M.; Zheng, S.; Fang, M.; Yi, T.-H. Rosa davurica Inhibited Allergic Mediators by Regulating Calcium and Histamine Signaling Pathways. Plants 2023, 12, 1572. https://doi.org/10.3390/plants12071572

AMA Style

Lim S, Oh S, Nguyen QTN, Kim M, Zheng S, Fang M, Yi T-H. Rosa davurica Inhibited Allergic Mediators by Regulating Calcium and Histamine Signaling Pathways. Plants. 2023; 12(7):1572. https://doi.org/10.3390/plants12071572

Chicago/Turabian Style

Lim, Seojun, Sarang Oh, Quynh T. N. Nguyen, Myeongju Kim, Shengdao Zheng, Minzhe Fang, and Tae-Hoo Yi. 2023. "Rosa davurica Inhibited Allergic Mediators by Regulating Calcium and Histamine Signaling Pathways" Plants 12, no. 7: 1572. https://doi.org/10.3390/plants12071572

APA Style

Lim, S., Oh, S., Nguyen, Q. T. N., Kim, M., Zheng, S., Fang, M., & Yi, T.-H. (2023). Rosa davurica Inhibited Allergic Mediators by Regulating Calcium and Histamine Signaling Pathways. Plants, 12(7), 1572. https://doi.org/10.3390/plants12071572

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