Next Article in Journal
Phytotoxic Activity of p-Cresol, 2-Phenylethanol and 3-Phenyl-1-Propanol, Phenolic Compounds Present in Cistus ladanifer L.
Next Article in Special Issue
Diterpene Resin Acids and Olefins in Calabrian Pine (Pinus nigra subsp. laricio (Poiret) Maire) Oleoresin: GC-MS Profiling of Major Diterpenoids in Different Plant Organs, Molecular Identification and Expression Analysis of Diterpene Synthase Genes
Previous Article in Journal
Blurring the Boundaries between a Branch and a Flower: Potential Developmental Venues in CACTACEAE
Previous Article in Special Issue
Metabolomic Analysis of Cannabinoid and Essential Oil Profiles in Different Hemp (Cannabis sativa L.) Phenotypes
Article

Chemical Profiling, Pharmacological Insights and In Silico Studies of Methanol Seed Extract of Sterculia foetida

1
Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh
2
Drug Discovery, GUSTO A Research Group, Chittagong 4203, Bangladesh
3
Faculty of Medicine, Rangpur Medical College, Rajshahi Medical University, Rajshahi 6000, Bangladesh
4
Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh
5
Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo–Ourense Campus, E32004 Ourense, Spain
*
Authors to whom correspondence should be addressed.
Academic Editors: Mitja Kolar and Iztok Jože Košir
Plants 2021, 10(6), 1135; https://doi.org/10.3390/plants10061135
Received: 24 April 2021 / Revised: 26 May 2021 / Accepted: 31 May 2021 / Published: 3 June 2021
(This article belongs to the Special Issue Plant Analytical Chemistry)
Sterculia foetida, also known as jangli badam in Bangladesh, is a traditionally used plant that has pharmacological activities. A qualitative phytochemical analysis was performed to assess the metabolites in a methanolic extract of S. foetida seeds (MESF), and the cytotoxic, thrombolytic, anti-arthritics, analgesic, and antipyretic activities were examined using in vitro, in vivo, and in silico experiments. Quantitative studies were performed through gas chromatography-mass spectroscopy (GC-MS) analysis. The brine shrimp lethality bioassays and clot lysis were performed to investigate the cytotoxic and thrombolytic activities, respectively. The anti-arthritics activity was assessed using the albumin denaturation assay. Analgesic activity was determined using the acetic acid-induced writhing test and the formalin-induced paw-licking test. A molecular docking study was performed, and an online tool was used to perform ADME/T (absorption, distribution, metabolism, and excretion/toxicity) and PASS (Prediction of Activity Spectra for Substances). GC-MS analysis identified 29 compounds in MESF, consisting primarily of phenols, terpenoids, esters, and other organic compounds. MESF showed moderate cytotoxic activity against brine shrimp and significant thrombolytic and anti-arthritics activities compared with the relative standards. The extract also showed a dose-dependent and significant analgesic and antipyretic activities. Docking studies showed that 1-azuleneethanol, acetate returned the best scores for the tested enzymes. These findings suggested that MESF represents a potent source of thrombolytic, anti-arthritic, analgesic, antipyretic agents with moderate cytotoxic effects. View Full-Text
Keywords: Sterculia foetida; GC-MS; cytotoxic; thrombolytic; analgesic; antipyretic; molecular docking Sterculia foetida; GC-MS; cytotoxic; thrombolytic; analgesic; antipyretic; molecular docking
Show Figures

Graphical abstract

MDPI and ACS Style

Alam, N.; Banu, N.; Aziz, M.A.I.; Barua, N.; Ruman, U.; Jahan, I.; Chy, F.J.; Denath, S.; Paul, A.; Chy, M.N.U.; Sayeed, M.A.; Emran, T.B.; Simal-Gandara, J. Chemical Profiling, Pharmacological Insights and In Silico Studies of Methanol Seed Extract of Sterculia foetida. Plants 2021, 10, 1135. https://doi.org/10.3390/plants10061135

AMA Style

Alam N, Banu N, Aziz MAI, Barua N, Ruman U, Jahan I, Chy FJ, Denath S, Paul A, Chy MNU, Sayeed MA, Emran TB, Simal-Gandara J. Chemical Profiling, Pharmacological Insights and In Silico Studies of Methanol Seed Extract of Sterculia foetida. Plants. 2021; 10(6):1135. https://doi.org/10.3390/plants10061135

Chicago/Turabian Style

Alam, Najmul, Naureen Banu, Md. A.I. Aziz, Niloy Barua, Umme Ruman, Israt Jahan, Farhana J. Chy, Susmita Denath, Arkajyoti Paul, Md. N.U. Chy, Mohammed A. Sayeed, Talha B. Emran, and Jesus Simal-Gandara. 2021. "Chemical Profiling, Pharmacological Insights and In Silico Studies of Methanol Seed Extract of Sterculia foetida" Plants 10, no. 6: 1135. https://doi.org/10.3390/plants10061135

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop