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Article

Hibiscus sabdariffa, a Treatment for Uncontrolled Hypertension. Pilot Comparative Intervention

1
Antenna Foundation, Avenue de la Grenade 24, 1207 Geneva, Switzerland
2
The Iraq Health Access Organization (“IHAO”), District 901, Abu Nawas ST, Baghdad, Iraq
3
School of Pharmaceutical Sciences, University of Geneva, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
4
Institute of Pharmaceutical Sciences of Western Switzerland (ISPSW), University of Geneva, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
5
WStats Limited, 8, The Mons, Winchester SO23 8GH, UK
*
Author to whom correspondence should be addressed.
This author contributed equally to this work.
Academic Editors: Ina Vandebroek, Rupika Delgoda and David Picking
Plants 2021, 10(5), 1018; https://doi.org/10.3390/plants10051018
Received: 22 February 2021 / Revised: 4 May 2021 / Accepted: 11 May 2021 / Published: 19 May 2021
(This article belongs to the Special Issue Ethnobotany and Community Health)
In Iraq, in 2019, there were about 1.4 million Internally Displaced Persons (IDP); medical treatments were often interrupted. The feasibility of using Hibiscus sabdariffa (HS) decoction to curb hypertension was evaluated. A multicentric comparative pilot intervention for 121 participants with high blood pressure (BP) (≥140/90 mmHg) was conducted. Participants of the intervention group (with or without conventional medication) received HS decoction on a dose regimen starting from 10 grams per day. BP was measured five times over six weeks. The major active substances were chemically quantified. Results: After 6 weeks, 61.8% of participants from the intervention group (n = 76) reached the target BP < 140/90 mmHg, compared to 6.7% in the control group (n = 45). In the intervention group, a mean (±SD) reduction of 23.1 (±11.8) mmHg and 12.0 (±11.2) for systolic and diastolic BP, respectively, was observed, while in the control group the reduction was 4.4 (±10.2)/3.6 (±8.7). The chemical analysis of the starting dose indicated a content of 36 mg of total anthocyanins and 2.13 g of hibiscus acid. The study shows the feasibility of using HS decoction in IDP’s problematic framework, as hibiscus is a safe, local, affordable, and culturally accepted food product. View Full-Text
Keywords: Hibiscus sabdariffa; Iraq; hypertension; IDP; refugees Hibiscus sabdariffa; Iraq; hypertension; IDP; refugees
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MDPI and ACS Style

Al-Anbaki, M.; Cavin, A.-L.; Nogueira, R.C.; Taslimi, J.; Ali, H.; Najem, M.; Shukur Mahmood, M.; Abdullah Khaleel, I.; Saad Mohammed, A.; Ramadhan Hasan, H.; Marcourt, L.; Félix, F.; Vinh Tri Low-Der’s, N.; Ferreira Queiroz, E.; Wolfender, J.-L.; Watissée, M.; Graz, B. Hibiscus sabdariffa, a Treatment for Uncontrolled Hypertension. Pilot Comparative Intervention. Plants 2021, 10, 1018. https://doi.org/10.3390/plants10051018

AMA Style

Al-Anbaki M, Cavin A-L, Nogueira RC, Taslimi J, Ali H, Najem M, Shukur Mahmood M, Abdullah Khaleel I, Saad Mohammed A, Ramadhan Hasan H, Marcourt L, Félix F, Vinh Tri Low-Der’s N, Ferreira Queiroz E, Wolfender J-L, Watissée M, Graz B. Hibiscus sabdariffa, a Treatment for Uncontrolled Hypertension. Pilot Comparative Intervention. Plants. 2021; 10(5):1018. https://doi.org/10.3390/plants10051018

Chicago/Turabian Style

Al-Anbaki, Marwah, Anne-Laure Cavin, Renata C. Nogueira, Jaafar Taslimi, Hayder Ali, Mohammed Najem, Mustafa Shukur Mahmood, Ibrahim Abdullah Khaleel, Abdulqader Saad Mohammed, Hasan Ramadhan Hasan, Laurence Marcourt, Fabien Félix, Nicolas Vinh Tri Low-Der’s, Emerson Ferreira Queiroz, Jean-Luc Wolfender, Marie Watissée, and Bertrand Graz. 2021. "Hibiscus sabdariffa, a Treatment for Uncontrolled Hypertension. Pilot Comparative Intervention" Plants 10, no. 5: 1018. https://doi.org/10.3390/plants10051018

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