Zebrafish Optomotor Response and Morphology Are Altered by Transient, Developmental Exposure to Bisphenol-A
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animal Maintenance
2.2. Exposures
2.3. Behavioral Assays
2.3.1. Startle Response
2.3.2. Optomotor Response
2.4. Morphometric Analysis
2.5. Statistical Analysis
3. Results
3.1. Suvival
3.2. Morphometric Results
3.2.1. 24 hpf Exposures
3.2.2. 72 hpf Exposures
3.3. Behavioral Responses
3.3.1. 24 hpf Exposures
3.3.2. 72 hpf Exposures
3.3.3. 7 dpf Exposures
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
4-OH-A | 4-hydroxyandrostenedione |
BPA | bisphenol-A |
dpf | days post-fertilization |
DMSO | dimethyl sulfoxide |
EDCs | endocrine disrupting compounds |
ER | estrogen receptor |
ERRγ | estrogen related receptors |
ED | eye diameter |
GPER | G-protein coupled estrogen receptor |
hpf | hours post-fertilization |
NL | notochord length |
OMR | optomotor response |
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Crowley-Perry, M.; Barberio, A.J.; Zeino, J.; Winston, E.R.; Connaughton, V.P. Zebrafish Optomotor Response and Morphology Are Altered by Transient, Developmental Exposure to Bisphenol-A. J. Dev. Biol. 2021, 9, 14. https://doi.org/10.3390/jdb9020014
Crowley-Perry M, Barberio AJ, Zeino J, Winston ER, Connaughton VP. Zebrafish Optomotor Response and Morphology Are Altered by Transient, Developmental Exposure to Bisphenol-A. Journal of Developmental Biology. 2021; 9(2):14. https://doi.org/10.3390/jdb9020014
Chicago/Turabian StyleCrowley-Perry, Mikayla, Angelo J. Barberio, Jude Zeino, Erica R. Winston, and Victoria P. Connaughton. 2021. "Zebrafish Optomotor Response and Morphology Are Altered by Transient, Developmental Exposure to Bisphenol-A" Journal of Developmental Biology 9, no. 2: 14. https://doi.org/10.3390/jdb9020014