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Axin Family of Scaffolding Proteins in Development: Lessons from C. elegans

1
Department of Biology, McMaster University, Hamilton, ON L8S-4K1, Canada
2
Department of Bioengineering, Northeastern University, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
J. Dev. Biol. 2019, 7(4), 20; https://doi.org/10.3390/jdb7040020
Received: 12 August 2019 / Revised: 7 October 2019 / Accepted: 11 October 2019 / Published: 15 October 2019
(This article belongs to the Special Issue Caenorhabditis elegans - A Developmental Genetic Model System)
Scaffold proteins serve important roles in cellular signaling by integrating inputs from multiple signaling molecules to regulate downstream effectors that, in turn, carry out specific biological functions. One such protein, Axin, represents a major evolutionarily conserved scaffold protein in metazoans that participates in the WNT pathway and other pathways to regulate diverse cellular processes. This review summarizes the vast amount of literature on the regulation and functions of the Axin family of genes in eukaryotes, with a specific focus on Caenorhabditis elegans development. By combining early studies with recent findings, the review is aimed to serve as an updated reference for the roles of Axin in C. elegans and other model systems. View Full-Text
Keywords: Axin; C. elegans; pry-1; axl-1; WNT signaling; scaffolding protein; signal transduction; development Axin; C. elegans; pry-1; axl-1; WNT signaling; scaffolding protein; signal transduction; development
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Mallick, A.; Taylor, S.K.B.; Ranawade, A.; Gupta, B.P. Axin Family of Scaffolding Proteins in Development: Lessons from C. elegans. J. Dev. Biol. 2019, 7, 20.

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