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Sonic Hedgehog—‘Jack-of-All-Trades’ in Neural Circuit Formation

Department of Molecular Life Sciences and Neuroscience Center Zurich, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Author to whom correspondence should be addressed.
Academic Editors: Henk Roelink and Simon J. Conway
J. Dev. Biol. 2017, 5(1), 2;
Received: 29 November 2016 / Revised: 22 January 2017 / Accepted: 1 February 2017 / Published: 8 February 2017
(This article belongs to the Collection Hedgehog Signaling in Embryogenesis)
As reflected by the term morphogen, molecules such as Shh and Wnts were identified based on their role in early development when they instruct precursor cells to adopt a specific cell fate. Only much later were they implicated in neural circuit formation. Both in vitro and in vivo studies indicated that morphogens direct axons during their navigation through the developing nervous system. Today, the best understood role of Shh and Wnt in axon guidance is their effect on commissural axons in the spinal cord. Shh was shown to affect commissural axons both directly and indirectly via its effect on Wnt signaling. In fact, throughout neural circuit formation there is cross-talk and collaboration of Shh and Wnt signaling. Thus, although the focus of this review is on the role of Shh in neural circuit formation, a separation from Wnt signaling is not possible. View Full-Text
Keywords: axon guidance; commissural axons; midline crossing; synaptogenesis axon guidance; commissural axons; midline crossing; synaptogenesis
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Zuñiga, N.R.; Stoeckli, E.T. Sonic Hedgehog—‘Jack-of-All-Trades’ in Neural Circuit Formation. J. Dev. Biol. 2017, 5, 2.

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