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Hedgehog Signalling in the Embryonic Mouse Thymus

Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Henk Roelink and Simon J. Conway
J. Dev. Biol. 2016, 4(3), 22; https://doi.org/10.3390/jdb4030022
Received: 14 June 2016 / Revised: 11 July 2016 / Accepted: 14 July 2016 / Published: 16 July 2016
(This article belongs to the Collection Hedgehog Signaling in Embryogenesis)
T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte–TEC cross-talk in the embryonic mouse thymus during the last week of gestation. View Full-Text
Keywords: thymus; Hedgehog; Shh; Ihh; T cell development; thymic epithelial cell (TEC); Gli3; Gli2; Gli1 thymus; Hedgehog; Shh; Ihh; T cell development; thymic epithelial cell (TEC); Gli3; Gli2; Gli1
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MDPI and ACS Style

Barbarulo, A.; Lau, C.-I.; Mengrelis, K.; Ross, S.; Solanki, A.; Saldaña, J.I.; Crompton, T. Hedgehog Signalling in the Embryonic Mouse Thymus. J. Dev. Biol. 2016, 4, 22. https://doi.org/10.3390/jdb4030022

AMA Style

Barbarulo A, Lau C-I, Mengrelis K, Ross S, Solanki A, Saldaña JI, Crompton T. Hedgehog Signalling in the Embryonic Mouse Thymus. Journal of Developmental Biology. 2016; 4(3):22. https://doi.org/10.3390/jdb4030022

Chicago/Turabian Style

Barbarulo, Alessandro; Lau, Ching-In; Mengrelis, Konstantinos; Ross, Susan; Solanki, Anisha; Saldaña, José I.; Crompton, Tessa. 2016. "Hedgehog Signalling in the Embryonic Mouse Thymus" J. Dev. Biol. 4, no. 3: 22. https://doi.org/10.3390/jdb4030022

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