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Hedgehog Signalling in the Embryonic Mouse Thymus

Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Henk Roelink and Simon J. Conway
J. Dev. Biol. 2016, 4(3), 22;
Received: 14 June 2016 / Revised: 11 July 2016 / Accepted: 14 July 2016 / Published: 16 July 2016
(This article belongs to the Collection Hedgehog Signaling in Embryogenesis)
PDF [4159 KB, uploaded 16 July 2016]


T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte–TEC cross-talk in the embryonic mouse thymus during the last week of gestation. View Full-Text
Keywords: thymus; Hedgehog; Shh; Ihh; T cell development; thymic epithelial cell (TEC); Gli3; Gli2; Gli1 thymus; Hedgehog; Shh; Ihh; T cell development; thymic epithelial cell (TEC); Gli3; Gli2; Gli1

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Barbarulo, A.; Lau, C.-I.; Mengrelis, K.; Ross, S.; Solanki, A.; Saldaña, J.I.; Crompton, T. Hedgehog Signalling in the Embryonic Mouse Thymus. J. Dev. Biol. 2016, 4, 22.

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