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Open AccessArticle

The Epicardium in the Embryonic and Adult Zebrafish

Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, calle Melchor Fernández Almagro 3, 28029 Madrid, Spain
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
Harvard Medical School, Boston, MA 02115, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Dev. Biol. 2014, 2(2), 101-116;
Received: 8 February 2014 / Revised: 24 February 2014 / Accepted: 26 February 2014 / Published: 11 April 2014
(This article belongs to the Special Issue Epicardial Development and Cardiovascular Disease)
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The epicardium is the mesothelial outer layer of the vertebrate heart. It plays an important role during cardiac development by, among other functions, nourishing the underlying myocardium, contributing to cardiac fibroblasts and giving rise to the coronary vasculature. The epicardium also exerts key functions during injury responses in the adult and contributes to cardiac repair. In this article, we review current knowledge on the cellular and molecular mechanisms underlying epicardium formation in the zebrafish, a teleost fish, which is rapidly gaining status as an animal model in cardiovascular research, and compare it with the mechanisms described in other vertebrate models. We moreover describe the expression patterns of a subset of available zebrafish Wilms’ tumor 1 transgenic reporter lines and discuss their specificity, applicability and limitations in the study of epicardium formation. View Full-Text
Keywords: proepicardium; epicardium; zebrafish; development; regeneration; wt1a; wt1b proepicardium; epicardium; zebrafish; development; regeneration; wt1a; wt1b

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Peralta, M.; González-Rosa, J.M.; Marques, I.J.; Mercader, N. The Epicardium in the Embryonic and Adult Zebrafish. J. Dev. Biol. 2014, 2, 101-116.

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