The Epicardium and the Development of the Atrioventricular Junction in the Murine Heart
Abstract
:1. Development of the Atrioventricular Junction; a Short Introduction
1.1. Remodeling of the Myocardial AV Junction and Formation of the Annulus Fibrosus
1.2. Formation of the AV Valves
2. The Role of the Epicardium in AV Junction Development
2.1. The Epicardium in the Mouse
2.2. “Epicardial-Cre” Mouse Models
2.3. Cascade of Events Involved in Epicardial Contribution to AV Development
3. Contribution of EPDCs to the AV Junctional Tissues
3.1. Formation of the AV Epicardium
3.2. Epicardial EMT at the AV Junction and Formation of the AV Sulcus
3.3. The Annulus Fibrosus
3.4. EPDCs in the Leaflets of the AV Valves
4. Discussion and Future Directions
Acknowledgements
Conflicts of Interest
References and Notes
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Lockhart, M.M.; Phelps, A.L.; Van den Hoff, M.J.B.; Wessels, A. The Epicardium and the Development of the Atrioventricular Junction in the Murine Heart. J. Dev. Biol. 2014, 2, 1-17. https://doi.org/10.3390/jdb2010001
Lockhart MM, Phelps AL, Van den Hoff MJB, Wessels A. The Epicardium and the Development of the Atrioventricular Junction in the Murine Heart. Journal of Developmental Biology. 2014; 2(1):1-17. https://doi.org/10.3390/jdb2010001
Chicago/Turabian StyleLockhart, Marie M., Aimee L. Phelps, Maurice J. B. Van den Hoff, and Andy Wessels. 2014. "The Epicardium and the Development of the Atrioventricular Junction in the Murine Heart" Journal of Developmental Biology 2, no. 1: 1-17. https://doi.org/10.3390/jdb2010001