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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2015, 83(3), 511-518; (registering DOI)

Dosage Form Data Used for Estimating Pediatric Antibiotic Use

Department of Clinical Pharmacy, Faculty of Pharmacy, University of Szeged, Szikra utca 8., H-6725 Szeged, Hungary
Centre for Research and Innovation in Care (CRIC), Faculty of Medicine and Health Sciences, University of Antwerp, CDE R3.29, Universiteitsplein 1, B-2610 Wilrijk, Belgium
First Internal Medicine, Infectiology Unit, Faculty of Medicine, University of Szeged, Kálvária sgt 57, H-6724 Szeged, Hungary
Author to whom correspondence should be addressed.
Received: 11 November 2014 / Accepted: 1 July 2015 / Published: 1 July 2015
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We aimed to report a simple estimation method to enable quantification of pediatric antibiotic exposure in large aggregated datasets. Secondly, we aimed to quantify and benchmark Hungarian pediatric antibiotic use. First we intended to examine whether a correlation existed between dosage form data and the patient’s age. Therefore, issued prescriptions were analyzed in pharmacies. As a correlation was found between the share of liquid oral antibacterial products and the rate of pediatric antibiotic prescriptions (R=0.884; p<0.001), we extrapolated this finding to a large aggregated dataset and estimated that 34.6% of prescriptions were issued for pediatric cases (95% confidence interval: 19.7–60.0). Taking into account the demography of the population, children were exposed to antibiotics three times more often than adults with a corresponding annual prescription rate of 2.6. We demonstrated that simple drug-related data can be linked to a patient-related measure as we found strong associations between dosage form data and patients’ age. Based on this association, massive pediatric antibiotic exposure was found. Due to the general availability of dosage form data and the ease of the estimation method, the reported concept can be used to quantify pediatric antibiotic use in large aggregated datasets or when age stratification is absent.
Keywords: Pediatric antibiotic use; New estimation method; Pharmacoepidemiology; Liquid oral formulations; Drug utilization research Pediatric antibiotic use; New estimation method; Pharmacoepidemiology; Liquid oral formulations; Drug utilization research
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MATUZ, M.; BENKO, R.; ELSEVIERS, M.; HAJDU, E.; DORO, P.; VIOLA, R.; SOOS, G. Dosage Form Data Used for Estimating Pediatric Antibiotic Use. Sci. Pharm. 2015, 83, 511-518.

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