Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015).
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Sci. Pharm. 2015, 83(1), 49-63; https://doi.org/10.3797/scipharm.1407-14 (registering DOI)
Synthesis and Characterization of Impurities in the Production Process of Lopinavir
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad-502329, Telangana State, India
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, India
Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam-530 003, Andhra Pradesh, India
Author to whom correspondence should be addressed.
Received: 22 July 2014 / Accepted: 22 September 2014 / Published: 22 September 2014
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Abstract Lopinavir is an antiretroviral drug used for the inhibition of HIV protease. Four related substances of lopinavir were observed during the manufacturing process of lopinavir in the laboratory and they were identified. The present work describes the origin, synthesis, characterization, and control of these related substances.
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RAGHAVA REDDY, A.V.; GARAGA, S.; TAKSHINAMOORTHY, C.; NAIDU, A. Synthesis and Characterization of Impurities in the Production Process of Lopinavir. Sci. Pharm. 2015, 83, 49-63.
RAGHAVA REDDY AV, GARAGA S, TAKSHINAMOORTHY C, NAIDU A. Synthesis and Characterization of Impurities in the Production Process of Lopinavir. Scientia Pharmaceutica. 2015; 83(1):49-63.
RAGHAVA REDDY, Ambati V.; GARAGA, Srinivas; TAKSHINAMOORTHY, Chandiran; NAIDU, Andra. 2015. "Synthesis and Characterization of Impurities in the Production Process of Lopinavir." Sci. Pharm. 83, no. 1: 49-63.
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