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Scientia Pharmaceutica
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  • Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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22 September 2014

Synthesis and Characterization of Impurities in the Production Process of Lopinavir

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1
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad-502329, Telangana State, India
2
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, India
3
Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam-530 003, Andhra Pradesh, India
*
Author to whom correspondence should be addressed.
Sci. Pharm.2015, 83(1), 49-63;https://doi.org/10.3797/scipharm.1407-14
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Abstract

Lopinavir is an antiretroviral drug used for the inhibition of HIV protease. Four related substances of lopinavir were observed during the manufacturing process of lopinavir in the laboratory and they were identified. The present work describes the origin, synthesis, characterization, and control of these related substances.

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