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Volume 83
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Synthesis and Characterization of Impurities in the Production Process of Lopinavir

by
Ambati V. RAGHAVA REDDY
1,2,
Srinivas GARAGA
1,3,*,
Chandiran TAKSHINAMOORTHY
1 and
Andra NAIDU
2
1
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad-502329, Telangana State, India
2
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, India
3
Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam-530 003, Andhra Pradesh, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2015, 83(1), 49-63; https://doi.org/10.3797/scipharm.1407-14
Submission received: 22 July 2014 / Accepted: 22 September 2014 / Published: 22 September 2014
Versions Notes

Abstract

Lopinavir is an antiretroviral drug used for the inhibition of HIV protease. Four related substances of lopinavir were observed during the manufacturing process of lopinavir in the laboratory and they were identified. The present work describes the origin, synthesis, characterization, and control of these related substances.
Keywords: Lopinavir; Related substances; Synthesis and Characterization of impurities Lopinavir; Related substances; Synthesis and Characterization of impurities

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MDPI and ACS Style

RAGHAVA REDDY, A.V.; GARAGA, S.; TAKSHINAMOORTHY, C.; NAIDU, A. Synthesis and Characterization of Impurities in the Production Process of Lopinavir. Sci. Pharm. 2015, 83, 49-63. https://doi.org/10.3797/scipharm.1407-14

AMA Style

RAGHAVA REDDY AV, GARAGA S, TAKSHINAMOORTHY C, NAIDU A. Synthesis and Characterization of Impurities in the Production Process of Lopinavir. Scientia Pharmaceutica. 2015; 83(1):49-63. https://doi.org/10.3797/scipharm.1407-14

Chicago/Turabian Style

RAGHAVA REDDY, Ambati V., Srinivas GARAGA, Chandiran TAKSHINAMOORTHY, and Andra NAIDU. 2015. "Synthesis and Characterization of Impurities in the Production Process of Lopinavir" Scientia Pharmaceutica 83, no. 1: 49-63. https://doi.org/10.3797/scipharm.1407-14

APA Style

RAGHAVA REDDY, A. V., GARAGA, S., TAKSHINAMOORTHY, C., & NAIDU, A. (2015). Synthesis and Characterization of Impurities in the Production Process of Lopinavir. Scientia Pharmaceutica, 83(1), 49-63. https://doi.org/10.3797/scipharm.1407-14

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