Next Article in Journal
Development of Press-Coated, Floating-Pulsatile Drug Delivery of Lisinopril
Previous Article in Journal
Synthesis and Anticancer Activity of 2-(Alkyl-, Alkaryl-, Aryl-, Hetaryl-)-[1,2,4]triazolo[1,5-c]quinazolines
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 82
Issue 2
10.3797/scipharm.1309-17
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies

by
Marina ZACCHIGNA
1,*,
Francesca CATENI
1,
Sara DRIOLI
1,
Giuseppe PROCIDA
1 and
Tiziano ALTIERI
2
1
Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy
2
School of Advanced Studies ”G. D’Annunzio”, University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo, Chieti, Italy
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2014, 82(2), 411-422; https://doi.org/10.3797/scipharm.1309-17
Submission received: 25 September 2013 / Accepted: 6 April 2014 / Published: 6 April 2014
Versions Notes

Abstract

A highly water-soluble macromolecular compound of ursolic acid with mono-methoxypoly(ethylene glycol) (mPEG) was prepared. The physicochemical properties and stabilities under different conditions were investigated. By PEG conjugation, greatly increased water solubility was obtained, and the results showed that this conjugate was a potential prodrug for the oral delivery of ursolic acid.
Keywords: Ursolic acid; Monomethoxypoly(ethylene glycol); Conjugation; Solubility Ursolic acid; Monomethoxypoly(ethylene glycol); Conjugation; Solubility

Share and Cite

MDPI and ACS Style

ZACCHIGNA, M.; CATENI, F.; DRIOLI, S.; PROCIDA, G.; ALTIERI, T. PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies. Sci. Pharm. 2014, 82, 411-422. https://doi.org/10.3797/scipharm.1309-17

AMA Style

ZACCHIGNA M, CATENI F, DRIOLI S, PROCIDA G, ALTIERI T. PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies. Scientia Pharmaceutica. 2014; 82(2):411-422. https://doi.org/10.3797/scipharm.1309-17

Chicago/Turabian Style

ZACCHIGNA, Marina, Francesca CATENI, Sara DRIOLI, Giuseppe PROCIDA, and Tiziano ALTIERI. 2014. "PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies" Scientia Pharmaceutica 82, no. 2: 411-422. https://doi.org/10.3797/scipharm.1309-17

APA Style

ZACCHIGNA, M., CATENI, F., DRIOLI, S., PROCIDA, G., & ALTIERI, T. (2014). PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies. Scientia Pharmaceutica, 82(2), 411-422. https://doi.org/10.3797/scipharm.1309-17

Article Metrics

Back to TopTop