PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies

Marina ZACCHIGNA; Francesca CATENI; Sara DRIOLI; Giuseppe PROCIDA; Tiziano ALTIERI

doi:10.3797/scipharm.1309-17

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Article

6 April 2014

PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies

and

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy

School of Advanced Studies ”G. D’Annunzio”, University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo, Chieti, Italy

Author to whom correspondence should be addressed.

Sci. Pharm.2014, 82(2), 411-422;https://doi.org/10.3797/scipharm.1309-17

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Abstract

A highly water-soluble macromolecular compound of ursolic acid with mono-methoxypoly(ethylene glycol) (mPEG) was prepared. The physicochemical properties and stabilities under different conditions were investigated. By PEG conjugation, greatly increased water solubility was obtained, and the results showed that this conjugate was a potential prodrug for the oral delivery of ursolic acid.

Keywords:

Ursolic acid; Monomethoxypoly(ethylene glycol); Conjugation; Solubility

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