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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2014, 82(2), 411-422;

PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy
School of Advanced Studies ”G. D’Annunzio”, University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo, Chieti, Italy
Author to whom correspondence should be addressed.
Received: 25 September 2013 / Accepted: 6 April 2014 / Published: 6 April 2014
PDF [157 KB, uploaded 27 September 2016]


A highly water-soluble macromolecular compound of ursolic acid with mono-methoxypoly(ethylene glycol) (mPEG) was prepared. The physicochemical properties and stabilities under different conditions were investigated. By PEG conjugation, greatly increased water solubility was obtained, and the results showed that this conjugate was a potential prodrug for the oral delivery of ursolic acid.
Keywords: Ursolic acid; Monomethoxypoly(ethylene glycol); Conjugation; Solubility Ursolic acid; Monomethoxypoly(ethylene glycol); Conjugation; Solubility
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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ZACCHIGNA, M.; CATENI, F.; DRIOLI, S.; PROCIDA, G.; ALTIERI, T. PEG–Ursolic Acid Conjugate: Synthesis and In Vitro Release Studies. Sci. Pharm. 2014, 82, 411-422.

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