Next Article in Journal
Scientia Pharmaceutica, Autorenhinweise 2013
Previous Article in Journal
Synthesis, Characterization, and In Vitro Evaluation of New Ibuprofen Polymeric Prodrugs Based on 2-Hydroxypropyl Methacrylate
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 82
Issue 2
10.3797/scipharm.1311-04
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Antimicrobial Activity of Novel C2-Substituted 1,4-Dihydropyridine Analogues

by
Petra OLEJNÍKOVÁ
1,*,
Ľubomír ŠVORC
2,
Denisa OLŠOVSKÁ
1,
Anna PANÁKOVÁ
1,
Zuzana VIHONSKÁ
1,
Katarína KOVARYOVÁ
1 and
Štefan MARCHALÍN
3
1
Department of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic
2
Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic
3
Department of Organic Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2014, 82(2), 221-232; https://doi.org/10.3797/scipharm.1311-04
Submission received: 4 November 2013 / Accepted: 12 January 2014 / Published: 12 January 2014
Versions Notes

Abstract

The antimicrobial activity of 3-methyl-5-isopropyl (or ethyl) 6-methyl-4-nitro-phenyl-1,4-dihydropyridine-3,5-dicarboxylate derivatives was evaluated. Prokaryotes (bacteria) appeared to be more sensitive to their antimicrobial activity than were eukaryotes (filamentous fungi). The best antibacterial activity was shown by derivative 33, which was able to inhibit the growth of Mycobacterium smegmatis (MIC33 = 9 μg.ml−1), Staphylococcus aureus (MIC33 = 25 μg.ml−1), and Escherichia coli (MIC33 = 100 μg.ml−1). In addition, derivative 4 demonstrated its antibacterial power on the acid-fast bacterial species M. smegmatis and on Gram-positive S. aureus. Focusing on the structure-activity relationship, it appears that the increase in the substituent bulk at the C2 position improved the antibacterial activity of the set of compounds studied. Derivatives 33 and 4, carrying 2-cyano-3-oxo-3-phenylprop-1-en-1-yl and allyliminomethyl groups, respectively, showed significantly higher inhibition activities on all tested microorganisms in comparison with the rest of the derivatives. This enhancement was also in good correlation with different log P values (lipophilicity parameter).
Keywords: 1,4-Dihydropyridine derivatives; Antibacterial activity; Antifungal activity; Lipophilicity 1,4-Dihydropyridine derivatives; Antibacterial activity; Antifungal activity; Lipophilicity

Share and Cite

MDPI and ACS Style

OLEJNÍKOVÁ, P.; ŠVORC, Ľ.; OLŠOVSKÁ, D.; PANÁKOVÁ, A.; VIHONSKÁ, Z.; KOVARYOVÁ, K.; MARCHALÍN, Š. Antimicrobial Activity of Novel C2-Substituted 1,4-Dihydropyridine Analogues. Sci. Pharm. 2014, 82, 221-232. https://doi.org/10.3797/scipharm.1311-04

AMA Style

OLEJNÍKOVÁ P, ŠVORC Ľ, OLŠOVSKÁ D, PANÁKOVÁ A, VIHONSKÁ Z, KOVARYOVÁ K, MARCHALÍN Š. Antimicrobial Activity of Novel C2-Substituted 1,4-Dihydropyridine Analogues. Scientia Pharmaceutica. 2014; 82(2):221-232. https://doi.org/10.3797/scipharm.1311-04

Chicago/Turabian Style

OLEJNÍKOVÁ, Petra, Ľubomír ŠVORC, Denisa OLŠOVSKÁ, Anna PANÁKOVÁ, Zuzana VIHONSKÁ, Katarína KOVARYOVÁ, and Štefan MARCHALÍN. 2014. "Antimicrobial Activity of Novel C2-Substituted 1,4-Dihydropyridine Analogues" Scientia Pharmaceutica 82, no. 2: 221-232. https://doi.org/10.3797/scipharm.1311-04

APA Style

OLEJNÍKOVÁ, P., ŠVORC, Ľ., OLŠOVSKÁ, D., PANÁKOVÁ, A., VIHONSKÁ, Z., KOVARYOVÁ, K., & MARCHALÍN, Š. (2014). Antimicrobial Activity of Novel C2-Substituted 1,4-Dihydropyridine Analogues. Scientia Pharmaceutica, 82(2), 221-232. https://doi.org/10.3797/scipharm.1311-04

Article Metrics

Back to TopTop