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Article

Evaluation of Serum Levels of HER2, MMP-9, Nitric Oxide, and Total Antioxidant Capacity in Egyptian Breast Cancer Patients: Correlation with Clinico-Pathological Parameters

1
artment of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt
2
Oncology Center, Mansoura University, Mansoura, 35516, Egypt
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2014, 82(1), 129-146; https://doi.org/10.3797/scipharm.1306-18
Received: 30 June 2013 / Accepted: 22 September 2013 / Published: 22 September 2013
Breast cancer is by far the most common cancer in women worldwide and the main cause of cancer-related mortality. Breast cancer accounts for 38% of all malignancies among Egyptian women. The aim of our study was to evaluate the serum levels of human epidermal growth factor receptor-2 (HER2), matrix metalloproteinase-9 (MMP-9), nitric oxide (NO), and total antioxidant capacity (TAC) in breast cancer patients and to correlate these markers with clinico-pathological parameters. Serum HER2, MMP-9, and carcinoma antigen 15-3 (CA 15-3) were assessed in 80 breast cancer patients and ten healthy subjects as a control group by the enzyme-linked immunosorbent assay (ELISA) technique while NO and TAC were assessed by a colorimetric method. Serum HER2 was ≥15 ng/mL in nine patients (11.3%). High HER2 ECD levels were significantly associated with tissue HER2 (P<0.0001), metastasis (P= 0.0024), and negativity of both estrogen (P=0.0075) and progesterone (P=0.0239) receptors. Serum MMP-9 (P=0.0013), NO (P<0.0001), and CA 15-3 (P<0.0001) were significantly increased while serum TAC was significantly (P=0.01) decreased in breast cancer patients as compared to the control group. Serum MMP-9 was increased significantly (P=0.028) in metastatic patients as compared to non-metastatic patients. We found a positive correlation between serum HER2 and CA 15-3 (r=36, p=0.005). In conclusion, serum HER2 reflects the tissue HER2 status of breast cancer, so the determination of serum HER2 is helpful in assessing HER2 status, but in addition, a high level may reflect metastatic disease. Also, serum MMP-9 can be useful for denoting the development of metastasis in breast cancer patients. Follow-up is needed to evaluate the value of serum HER2 and MMP-9 as prognostic markers.
Keywords: Human epidermal growth factor receptor-2 (HER2); Matrix metalloproteinase-9 (MMP-9); Nitric oxide (NO); Total antioxidant capacity (TAC); Carcinoma Antigen 15-3 (CA15-3); Breast cancer Human epidermal growth factor receptor-2 (HER2); Matrix metalloproteinase-9 (MMP-9); Nitric oxide (NO); Total antioxidant capacity (TAC); Carcinoma Antigen 15-3 (CA15-3); Breast cancer
MDPI and ACS Style

RASHAD, Y.A.; ELKHODARY, T.R.; EL-GAYAR, A.M.; EISSA, L.A. Evaluation of Serum Levels of HER2, MMP-9, Nitric Oxide, and Total Antioxidant Capacity in Egyptian Breast Cancer Patients: Correlation with Clinico-Pathological Parameters. Sci. Pharm. 2014, 82, 129-146. https://doi.org/10.3797/scipharm.1306-18

AMA Style

RASHAD YA, ELKHODARY TR, EL-GAYAR AM, EISSA LA. Evaluation of Serum Levels of HER2, MMP-9, Nitric Oxide, and Total Antioxidant Capacity in Egyptian Breast Cancer Patients: Correlation with Clinico-Pathological Parameters. Scientia Pharmaceutica. 2014; 82(1):129-146. https://doi.org/10.3797/scipharm.1306-18

Chicago/Turabian Style

RASHAD, Yara A., Tawfik R. ELKHODARY, Amal M. EL-GAYAR, and Laila A. EISSA 2014. "Evaluation of Serum Levels of HER2, MMP-9, Nitric Oxide, and Total Antioxidant Capacity in Egyptian Breast Cancer Patients: Correlation with Clinico-Pathological Parameters" Scientia Pharmaceutica 82, no. 1: 129-146. https://doi.org/10.3797/scipharm.1306-18

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