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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2012, 80(3), 779-788; https://doi.org/10.3797/scipharm.1205-15 (registering DOI)

Development and Characterization of Pharmacokinetic Parameters of Fast-Dissolving Films Containing Levocetirizine

1
Indukaka Ipcowala College of Pharmacy, New V V Nagar, Anand, Gujarat – 388121, India
2
College of Pharmacy, V V Nagar, Anand, Gujarat – 388120, India
*
Author to whom correspondence should be addressed.
Received: 31 May 2012 / Accepted: 22 July 2012 / Published: 22 July 2012
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Abstract

A fast-dissolving film containing levocetirizine, a non-sedative antihistamine drug, was developed using pullulan, xanthan gum, propylene glycol, and tween 80 as the base materials. The drug content of the prepared films was within an acceptable limit as prescribed by the USP. The film exhibited excellent stability for four months when stored at 40 °C and 75% humidity. In vitro dissolution studies suggested a rapid disintegration, in which most of levocetirizine (93.54 ± 3.9%) dissolved within 90 seconds after insertion into the medium. Subse-quently, Sprague–Dawley rats were used to compare the pharmacokinetic properties of the film preparation administered to the oral cavity, to those with oral administration of the pure drug solution. The pharmacokinetic parameters were similar between the two groups in which AUC0–t (ng h/ml), AUC0–∞ (ng h/ml) Cmax (ng/ml), Tmax (min), Kel (h−1), and t1/2 (h) of the reference were 452.033 ± 43.68, 465.78 ± 48.16, 237.16 ± 19.87, 30, 0.453 ± 0.051, and 1.536 ± 0.118, respectively, for the film formulation 447.233 ± 46.24, 458.22 ± 46.74, 233.32 ± 17.19, 30, 0.464 ± 0.060, and 1.496 ± 0.293, respectively. These results suggest that the present levocetirizine containing fast-dissolving film is likely to become one of the choices to treat different allergic conditions.
Keywords: Fast dissolving film; Levocetirizine; In-vitro dissolution studies; Pharmacokinetics; Drug content Fast dissolving film; Levocetirizine; In-vitro dissolution studies; Pharmacokinetics; Drug content
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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CHOUDHARY, D.R.; PATEL, V.A.; CHHALOTIYA, U.K.; PATEL, H.V.; KUNDAWALA, A.J. Development and Characterization of Pharmacokinetic Parameters of Fast-Dissolving Films Containing Levocetirizine. Sci. Pharm. 2012, 80, 779-788.

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