Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone
Institut für Pharmazie, Freie Universität Berlin, Königin-Luise-Straße 2+4, D-14195 Berlin, Germany
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Sci. Pharm. 2012, 80(3), 663-668; https://doi.org/10.3797/scipharm.1204-21
Submission received: 23 April 2012
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Accepted: 31 May 2012
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Published: 31 May 2012
Abstract
The cytotoxicity of alpha- and beta-asarone was investigated with the BrdU assay in HepG2-cells. Alpha-asarone was found to be more toxic than beta-asarone after 24 hours of treatment. Investigation of the genotoxicity using the micronucleus assay in the HepG2-cell system showed that only after metabolic activation by a liver microsomal preparation, beta-asarone was able to induce micronuclei at concentrations higher than 50 μg/mL.
Keywords:
Asarone; HepG2-cells; Cytotoxicity; Genotoxicity; Micronucleus test
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MDPI and ACS Style
UNGER, P.; MELZIG, M.F. Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone. Sci. Pharm. 2012, 80, 663-668. https://doi.org/10.3797/scipharm.1204-21
AMA Style
UNGER P, MELZIG MF. Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone. Scientia Pharmaceutica. 2012; 80(3):663-668. https://doi.org/10.3797/scipharm.1204-21
Chicago/Turabian StyleUNGER, Pascal, and Matthias F. MELZIG. 2012. "Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone" Scientia Pharmaceutica 80, no. 3: 663-668. https://doi.org/10.3797/scipharm.1204-21
