Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone

UNGER, Pascal; MELZIG, Matthias F.

doi:10.3797/scipharm.1204-21

Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Communication

31 May 2012

6 Pages

Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone

and

Institut für Pharmazie, Freie Universität Berlin, Königin-Luise-Straße 2+4, D-14195 Berlin, Germany

Author to whom correspondence should be addressed.

Sci. Pharm.2012, 80(3), 663-668;https://doi.org/10.3797/scipharm.1204-21

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Abstract

The cytotoxicity of alpha- and beta-asarone was investigated with the BrdU assay in HepG2-cells. Alpha-asarone was found to be more toxic than beta-asarone after 24 hours of treatment. Investigation of the genotoxicity using the micronucleus assay in the HepG2-cell system showed that only after metabolic activation by a liver microsomal preparation, beta-asarone was able to induce micronuclei at concentrations higher than 50 μg/mL.

Keywords:

Asarone; HepG2-cells; Cytotoxicity; Genotoxicity; Micronucleus test

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