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Sci. Pharm.Scientia Pharmaceutica
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31 May 2012

Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone

and
Institut für Pharmazie, Freie Universität Berlin, Königin-Luise-Straße 2+4, D-14195 Berlin, Germany
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Sci. Pharm.2012, 80(3), 663-668;https://doi.org/10.3797/scipharm.1204-21
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Abstract

The cytotoxicity of alpha- and beta-asarone was investigated with the BrdU assay in HepG2-cells. Alpha-asarone was found to be more toxic than beta-asarone after 24 hours of treatment. Investigation of the genotoxicity using the micronucleus assay in the HepG2-cell system showed that only after metabolic activation by a liver microsomal preparation, beta-asarone was able to induce micronuclei at concentrations higher than 50 μg/mL.

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