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Volume 80
Issue 3
10.3797/scipharm.1203-07
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Article

Simultaneous Estimation of Amlodipine Besylate and Indapamide in a Pharmaceutical Formulation by a High Performance Liquid Chromatographic (RP-HPLC) Method

by
Deval B. PATEL
*,
Falgun A. MEHTA
and
Kashyap K. BHATT
Department of Pharmaceutical Chemistry and Analysis, Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar – 388121, Gujarat, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2012, 80(3), 581-590; https://doi.org/10.3797/scipharm.1203-07
Submission received: 25 March 2012 / Accepted: 30 April 2012 / Published: 30 April 2012
Versions Notes

Abstract

An isocratic reversed-phase liquid chromatograpic assay method was developed for the quantitative determination of amlodipine besylate (AML) and indapamide (IND) in combined dosage form. A Brownlee C-18, 5 μm column with a mobile phase containing 0.02 M potassium dihydrogen phosphate–methanol (30+70, v/v) total pH-adjusted to 3 using o-phosphoric acid was used. The flow rate was 1.0 mL min−1 and effluents were monitored at 242 nm. The retention times of amlodipine besylate and indapamide were 5.9 min and 3.6 min, respectively. The proposed method was validated with respect to linearity, accuracy, precision, and robustness. The method was successfully applied to the estimation of amlodipine besylate and indapamide in combined tablet dosage forms.
Keywords: RP-HPLC; Amlodipine; Indapamide; Tablet; Validation RP-HPLC; Amlodipine; Indapamide; Tablet; Validation

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MDPI and ACS Style

PATEL, D.B.; MEHTA, F.A.; BHATT, K.K. Simultaneous Estimation of Amlodipine Besylate and Indapamide in a Pharmaceutical Formulation by a High Performance Liquid Chromatographic (RP-HPLC) Method. Sci. Pharm. 2012, 80, 581-590. https://doi.org/10.3797/scipharm.1203-07

AMA Style

PATEL DB, MEHTA FA, BHATT KK. Simultaneous Estimation of Amlodipine Besylate and Indapamide in a Pharmaceutical Formulation by a High Performance Liquid Chromatographic (RP-HPLC) Method. Scientia Pharmaceutica. 2012; 80(3):581-590. https://doi.org/10.3797/scipharm.1203-07

Chicago/Turabian Style

PATEL, Deval B., Falgun A. MEHTA, and Kashyap K. BHATT. 2012. "Simultaneous Estimation of Amlodipine Besylate and Indapamide in a Pharmaceutical Formulation by a High Performance Liquid Chromatographic (RP-HPLC) Method" Scientia Pharmaceutica 80, no. 3: 581-590. https://doi.org/10.3797/scipharm.1203-07

APA Style

PATEL, D. B., MEHTA, F. A., & BHATT, K. K. (2012). Simultaneous Estimation of Amlodipine Besylate and Indapamide in a Pharmaceutical Formulation by a High Performance Liquid Chromatographic (RP-HPLC) Method. Scientia Pharmaceutica, 80(3), 581-590. https://doi.org/10.3797/scipharm.1203-07

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