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Sci. Pharm. 2012, 80(3), 509-530; https://doi.org/10.3797/scipharm.1204-02 (registering DOI)
Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents
Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010, Lviv, Ukraine
Mutabilis, 102 Avenue Gaston Roussel, 93230 Romainville, France
Author to whom correspondence should be addressed.
Received: 2 April 2012 / Accepted: 3 May 2012 / Published: 3 May 2012
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Abstract rel-(5aR,11bR)-3,5a,6,11b-tetrahydro-2Н,5Н-chromeno[4',3':4,5]thiopyrano[2,3-d][1,3]thiazol-2-ones formed by the stereoselective Knoevenagel-hetero-Diels-Alder reaction were functionalized at the nitrogen in position 3 via reactions of alkylation, cyanoethylation, and acylation. The synthesized compounds were evaluated for their anticancer activity in NCI60 cell lines. Among the tested compounds, 3f was found to be the most active candidate with the greatest influence on leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, prostate cancer, and breast cancer subpanel cell lines with GI50 values over a range of 0.37–0.67 μM.
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KRYSHCHYSHYN, A.; ATAMANYUK, D.; LESYK, R. Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents. Sci. Pharm. 2012, 80, 509-530.
KRYSHCHYSHYN A, ATAMANYUK D, LESYK R. Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents. Scientia Pharmaceutica. 2012; 80(3):509-530.
KRYSHCHYSHYN, Anna; ATAMANYUK, Dmytro; LESYK, Roman. 2012. "Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents." Sci. Pharm. 80, no. 3: 509-530.
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