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Volume 80
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Protective Properties of Laggera alata Extract and its Principle Components Against D-Galactosamine-Injured Hepatocytes

by
Yi-Hang WU
1,*,
Bing-Jie HAO
1,
E SHEN
2,
Qing-Li MENG
1,
Ming-Hui HU
3 and
Yu ZHAO
3
1
Department of Pharmacy, College of Life Sciences, China Jiliang University, 310018 Hangzhou, China
2
Intensive Care Unit, Zhejiang Provincial People’s Hospital, 310005 Hangzhou, China
3
Department of Traditional Chinese Medicine and Natural Drug Research, Zhejiang University, 310058 Hangzhou, China
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2012, 80(2), 447-456; https://doi.org/10.3797/scipharm.1108-16
Submission received: 18 August 2011 / Accepted: 8 February 2012 / Published: 8 February 2012
Versions Notes

Abstract

Laggera alata extract (LAE) was quantitatively analyzed, and its principle components isochlorogenic acids were isolated and authenticated. Protective properties of LAE were studied using a D-galactosamine (D-GalN)-induced injury model in neonatal rat hepatocytes and a D-GalN-induced acute liver damage model in mice. Meanwhile, the effect of isochlorogenic acids derived from LAE on D-GalN-induced hepatocyte injury were also measured in vitro. LAE at concentrations of 10–100 μg/ml significantly reduced cellular leakage of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and improved cell viability. The isochlorogenic acids (4,5-O-dicaffeoylquinic acid, 3,5-O-dicaffeoylquinic acid and 3,4-O-dicaffeoylquinic acid) at concentrations of 1–100 μg/ml also remarkably improved viability of hepatocytes. The oral treatment of LAE at doses of 50, 100 and 200 mg/kg markedly reduced the serum AST and ALT activity of mice and resulted in significant recovery of hepatocytes in liver sections.
Keywords: Laggera alata extract; Isochlorogenic acid; D-Galactosamine; Hepatoprotective Laggera alata extract; Isochlorogenic acid; D-Galactosamine; Hepatoprotective

Share and Cite

MDPI and ACS Style

WU, Y.-H.; HAO, B.-J.; SHEN, E.; MENG, Q.-L.; HU, M.-H.; ZHAO, Y. Protective Properties of Laggera alata Extract and its Principle Components Against D-Galactosamine-Injured Hepatocytes. Sci. Pharm. 2012, 80, 447-456. https://doi.org/10.3797/scipharm.1108-16

AMA Style

WU Y-H, HAO B-J, SHEN E, MENG Q-L, HU M-H, ZHAO Y. Protective Properties of Laggera alata Extract and its Principle Components Against D-Galactosamine-Injured Hepatocytes. Scientia Pharmaceutica. 2012; 80(2):447-456. https://doi.org/10.3797/scipharm.1108-16

Chicago/Turabian Style

WU, Yi-Hang, Bing-Jie HAO, E SHEN, Qing-Li MENG, Ming-Hui HU, and Yu ZHAO. 2012. "Protective Properties of Laggera alata Extract and its Principle Components Against D-Galactosamine-Injured Hepatocytes" Scientia Pharmaceutica 80, no. 2: 447-456. https://doi.org/10.3797/scipharm.1108-16

APA Style

WU, Y. -H., HAO, B. -J., SHEN, E., MENG, Q. -L., HU, M. -H., & ZHAO, Y. (2012). Protective Properties of Laggera alata Extract and its Principle Components Against D-Galactosamine-Injured Hepatocytes. Scientia Pharmaceutica, 80(2), 447-456. https://doi.org/10.3797/scipharm.1108-16

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