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Scientia Pharmaceutica
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  • Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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12 February 2011

Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]- piperidine-2,6-diones

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1
Department of Medical Chemistry, First Faculty of Medicine, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland
2
Department of Crystallography, Faculty of Chemistry, Maria Curie-Sklodowska University, 3 Maria CurieSklodowska Square, 20-031 Lublin, Poland
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Department of Biomedical Science and Technology, University of Cagliari, 09042 Monserrato (CA), Italy
*
Author to whom correspondence should be addressed.
Sci. Pharm.2011, 79(2), 225-238;https://doi.org/10.3797/scipharm.1012-17
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Abstract

A set of 13 alkyl derivatives of 3-phenylpiperidine-2,6-dione were synthesized. Newly obtained compounds were investigated in vitro against HIV-1 and other selected viruses. The benzyl 3f and fluorophenyl 3g derivatives showed moderate protection against CVB-2 and the compound 3g also against HSV-1. Derivatives were tested also for their antibacterial and antifungal activity. The molecular structures of 3a and 3d were determined by an X-ray analysis.

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Scientia Pharmaceutica, Autorenhinweise 2011
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