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Sci. Pharm. 2011, 79(2), 225-238; https://doi.org/10.3797/scipharm.1012-17 (registering DOI)
Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]- piperidine-2,6-diones
Department of Medical Chemistry, First Faculty of Medicine, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland
Department of Crystallography, Faculty of Chemistry, Maria Curie-Sklodowska University, 3 Maria CurieSklodowska Square, 20-031 Lublin, Poland
Department of Biomedical Science and Technology, University of Cagliari, 09042 Monserrato (CA), Italy
Author to whom correspondence should be addressed.
Received: 16 December 2010 / Accepted: 10 February 2011 / Published: 12 February 2011
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Abstract A set of 13 alkyl derivatives of 3-phenylpiperidine-2,6-dione were synthesized. Newly obtained compounds were investigated in vitro against HIV-1 and other selected viruses. The benzyl 3f and fluorophenyl 3g derivatives showed moderate protection against CVB-2 and the compound 3g also against HSV-1. Derivatives were tested also for their antibacterial and antifungal activity. The molecular structures of 3a and 3d were determined by an X-ray analysis.
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BIELENICA, A.; KOSSAKOWSKI, J.; STRUGA, M.; DYBAŁA, I.; LODDO, R.; IBBA, C.; LA COLLA, P. Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]- piperidine-2,6-diones. Sci. Pharm. 2011, 79, 225-238.
BIELENICA A, KOSSAKOWSKI J, STRUGA M, DYBAŁA I, LODDO R, IBBA C, LA COLLA P. Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]- piperidine-2,6-diones. Scientia Pharmaceutica. 2011; 79(2):225-238.
BIELENICA, Anna; KOSSAKOWSKI, Jerzy; STRUGA, Marta; DYBAŁA, Izabela; LODDO, Roberta; IBBA, Cristina; LA COLLA, Paolo. 2011. "Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]- piperidine-2,6-diones." Sci. Pharm. 79, no. 2: 225-238.
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