Next Article in Journal
Development and Validation of a Dissolution Test for 6 mg Deflazacort Tablets
Previous Article in Journal
Design and Development of a Self Correcting Monolithic Gastroretentive Tablet of Baclofen
Article Menu

Article Versions

Export Article

Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessArticle
Sci. Pharm. 2009, 77(3), 669-678; (registering DOI)

Formulation and In Vitro Evaluation of Sunflower Oil Entrapped within Buoyant Beads of Furosemide

Pharmaceutics Research Laboratory-II, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
Author to whom correspondence should be addressed.
Received: 4 November 2008 / Accepted: 11 August 2009 / Published: 12 August 2009
PDF [249 KB, uploaded 21 December 2016]


The purpose of the present study was to develop buoyant beads for the intragastric delivery of furosemide in order to evaluate the effect of incorporated sunflower oil on physiochemical properties of alginate beads. Sunflower oil entrapped buoyant alginate beads of furosemide were prepared by the emulsion-gelation technique. During the preparation of various batches of beads, the ratio of sunflower oil to water (v/v), the ratio of drug to polymer (w/w), were kept as variables at two levels; either high or low. Smooth, spherical beads with nominal weight variation were obtained. All batches of beads floated for 24 hours with a lag time of 5–10 min. The release of drug followed for 5 hours. Higuchi and first order kinetic modeling indicated a diffusion-controlled release of drug from the beads. The study also demonstrated the influence of sunflower oil on drug entrapment (81–95%) and in vitro release. A higher level of oil increased drug entrapment efficiency but retarded drug release rate as compared to a lower level of oil containing beads.
Keywords: Furosemide; Alginate beads; Sunflower oil; Buoyant system Furosemide; Alginate beads; Sunflower oil; Buoyant system
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

BERA, R.; MANDAL, B.; BHOWMIK, M.; BERA, H.; DEY, S.K.; NANDI, G.; GHOSH, L.K. Formulation and In Vitro Evaluation of Sunflower Oil Entrapped within Buoyant Beads of Furosemide. Sci. Pharm. 2009, 77, 669-678.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics



[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top