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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2008, 76(4), 673-688; (registering DOI)

Activities of the Antipsychotic Drugs Haloperidol and Risperidone on Behavioural Effects Induced by Ketamine in Mice

Superior Institute of Biomedical Sciences, Academic Master in Physiological Sciences, State University of Ceará, Fortaleza, Ceará, Brazil
Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil
Author to whom correspondence should be addressed.
Received: 16 October 2008 / Accepted: 27 November 2008 / Published: 28 November 2008
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This study presents the actions of risperidone (Risp) and haloperidol (Hal) on the behavioral effects elicited by ketamine (Ket) on open-field (OF), rota rod (RR) and tail suspension (TS) tests in mice. Male Swiss albino mice (25–30g) were used. Antipsychotics were administered alone (Risp: 0.1 or 0.2 mg/kg, ip; Hal: 0.1 and 0.2 mg/kg, ip) or thirty minutes before Ket (10 mg/Kg, ip). Ket increased (Ket: 63.3 ± 4.2) the locomotor activity compared to control, while neuroleptics decreased it (25.5 ± 4.2). Pretreatment with neuroleptics, in both doses, blocked hyperlocomotion caused by Ket. In RR, Ket decreased (Ket: 15 ± 4.1) the permanence time of the animals compared to control (Control: 59 ± 0.6), but this effect was not observed when neuroleptics were administered alone. Pretreatment with neuroleptics reverted the effect of Ket only in the RR. While Ket (17.3 ± 5.6) decreased the time of immobility in the tail suspension test compared to the control (80.2 ± 10.2), the pretreatment with neuroleptics reverted this mobility. The action of neuroleptics in this model made possible the blockade of the effects caused by acute administration of Ket. Thus, the mechanism of action of ketamine may involve the dopaminergic system.
Keywords: Antipsychotic drug; Ketamine; Locomotor activity; Schizophrenia Antipsychotic drug; Ketamine; Locomotor activity; Schizophrenia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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ARRUDA, M.O.V.; SOARES, P.M.; HONÓRIO, J.E.R.; LIMA, R.C.S.; CHAVES, E.M.C.; LOBATO, R.F.G.; MARTIN, A.L.A.R.; SALES, G.T.M.; CARVALHO, K.M.; ASSREUY, A.M.S.; de BRITO, E.M.; VASCONCELOS, S.M.M. Activities of the Antipsychotic Drugs Haloperidol and Risperidone on Behavioural Effects Induced by Ketamine in Mice. Sci. Pharm. 2008, 76, 673-688.

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