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Article

Activities of the Antipsychotic Drugs Haloperidol and Risperidone on Behavioural Effects Induced by Ketamine in Mice

by
Marta De Oliveira Viana ARRUDA
1,
Paula Matias SOARES
1,
José Eduardo Ribeiro HONÓRIO
1,
Raquel Cristina de Sousa LIMA
1,
Edna Maria Camelo CHAVES
2,
Rodrigo De Freitas Guimarães LOBATO
2,
Ana Luíza de Aguiar Rocha MARTIN
2,
Gabriel Teixeira Montesuma SALES
2,
Krishnamurti De Moraes CARVALHO
1,
Ana Maria Sampaio ASSREUY
1,
Eliane Magalhães De BRITO
2 and
Silvânia Maria Mendes VASCONCELOS
2,*
1
Superior Institute of Biomedical Sciences, Academic Master in Physiological Sciences, State University of Ceará, Fortaleza, Ceará, Brazil
2
Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2008, 76(4), 673-688; https://doi.org/10.3797/scipharm.0810-11
Submission received: 16 October 2008 / Accepted: 27 November 2008 / Published: 28 November 2008
Versions Notes

Abstract

This study presents the actions of risperidone (Risp) and haloperidol (Hal) on the behavioral effects elicited by ketamine (Ket) on open-field (OF), rota rod (RR) and tail suspension (TS) tests in mice. Male Swiss albino mice (25–30g) were used. Antipsychotics were administered alone (Risp: 0.1 or 0.2 mg/kg, ip; Hal: 0.1 and 0.2 mg/kg, ip) or thirty minutes before Ket (10 mg/Kg, ip). Ket increased (Ket: 63.3 ± 4.2) the locomotor activity compared to control, while neuroleptics decreased it (25.5 ± 4.2). Pretreatment with neuroleptics, in both doses, blocked hyperlocomotion caused by Ket. In RR, Ket decreased (Ket: 15 ± 4.1) the permanence time of the animals compared to control (Control: 59 ± 0.6), but this effect was not observed when neuroleptics were administered alone. Pretreatment with neuroleptics reverted the effect of Ket only in the RR. While Ket (17.3 ± 5.6) decreased the time of immobility in the tail suspension test compared to the control (80.2 ± 10.2), the pretreatment with neuroleptics reverted this mobility. The action of neuroleptics in this model made possible the blockade of the effects caused by acute administration of Ket. Thus, the mechanism of action of ketamine may involve the dopaminergic system.
Keywords: Antipsychotic drug; Ketamine; Locomotor activity; Schizophrenia Antipsychotic drug; Ketamine; Locomotor activity; Schizophrenia

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MDPI and ACS Style

ARRUDA, M.D.O.V.; SOARES, P.M.; HONÓRIO, J.E.R.; LIMA, R.C.d.S.; CHAVES, E.M.C.; LOBATO, R.D.F.G.; MARTIN, A.L.d.A.R.; SALES, G.T.M.; CARVALHO, K.D.M.; ASSREUY, A.M.S.; et al. Activities of the Antipsychotic Drugs Haloperidol and Risperidone on Behavioural Effects Induced by Ketamine in Mice. Sci. Pharm. 2008, 76, 673-688. https://doi.org/10.3797/scipharm.0810-11

AMA Style

ARRUDA MDOV, SOARES PM, HONÓRIO JER, LIMA RCdS, CHAVES EMC, LOBATO RDFG, MARTIN ALdAR, SALES GTM, CARVALHO KDM, ASSREUY AMS, et al. Activities of the Antipsychotic Drugs Haloperidol and Risperidone on Behavioural Effects Induced by Ketamine in Mice. Scientia Pharmaceutica. 2008; 76(4):673-688. https://doi.org/10.3797/scipharm.0810-11

Chicago/Turabian Style

ARRUDA, Marta De Oliveira Viana, Paula Matias SOARES, José Eduardo Ribeiro HONÓRIO, Raquel Cristina de Sousa LIMA, Edna Maria Camelo CHAVES, Rodrigo De Freitas Guimarães LOBATO, Ana Luíza de Aguiar Rocha MARTIN, Gabriel Teixeira Montesuma SALES, Krishnamurti De Moraes CARVALHO, Ana Maria Sampaio ASSREUY, and et al. 2008. "Activities of the Antipsychotic Drugs Haloperidol and Risperidone on Behavioural Effects Induced by Ketamine in Mice" Scientia Pharmaceutica 76, no. 4: 673-688. https://doi.org/10.3797/scipharm.0810-11

APA Style

ARRUDA, M. D. O. V., SOARES, P. M., HONÓRIO, J. E. R., LIMA, R. C. d. S., CHAVES, E. M. C., LOBATO, R. D. F. G., MARTIN, A. L. d. A. R., SALES, G. T. M., CARVALHO, K. D. M., ASSREUY, A. M. S., De BRITO, E. M., & VASCONCELOS, S. M. M. (2008). Activities of the Antipsychotic Drugs Haloperidol and Risperidone on Behavioural Effects Induced by Ketamine in Mice. Scientia Pharmaceutica, 76(4), 673-688. https://doi.org/10.3797/scipharm.0810-11

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