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Article

Composition and stability of complexes of Ephedrine hydrochloride with Ni2+, Zn2+, and Cd2+ as toxic ions

by
Nabawia M. EL Guindi
National Organization for Drug Control and Research. Giza, Egypt
Sci. Pharm. 2003, 71(2), 75-88; https://doi.org/10.3797/scipharm.aut-03-09
Submission received: 5 November 2002 / Revised: 3 March 2003 / Accepted: 3 March 2003 / Published: 28 April 2003

Abstract

The complexes of Ephedrine with Nickel, Zinc and Cadmium ions have been investigated spectrophotometricalfy using the method of corresponding solutions [I-3] and pH-metrically using Irving and Rossoti technique [4] Two compositions were observed spectrophotometrically 1 : 1 and 2: 1 (L: M) for concentration of metal ions (0.5 x 10-3 M and 1 x 10-3 M) hile the first composition only predominate at concentration of metal ions (1.5 x 10-3 M and 2 x 10-3 M ). The stability of complexes show that complexes of Ni2+ are more stable than that of Zn2+ an Cd2+, Moreover, the composition and stabilities of complexes were studied pHmetrically in aqueous medium at 0.1 M NaCl and two different temperatures 30°C and 40°C; hence the value of the free energy change (ΔG°), the enthalpy (ΔH°) and the entropy (ΔS°) were calculated at 30°C. Beside the role of Ephedrine as chelating agent to toxic elements, the complexometric method was used for the determination of Ephedrine in its pure form and in tablets.
Keywords: Ephedrine determination; Metal ions; Spectrophotometry; Corresponding solutions method; Potentiometry Ephedrine determination; Metal ions; Spectrophotometry; Corresponding solutions method; Potentiometry

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MDPI and ACS Style

EL Guindi, N.M. Composition and stability of complexes of Ephedrine hydrochloride with Ni2+, Zn2+, and Cd2+ as toxic ions. Sci. Pharm. 2003, 71, 75-88. https://doi.org/10.3797/scipharm.aut-03-09

AMA Style

EL Guindi NM. Composition and stability of complexes of Ephedrine hydrochloride with Ni2+, Zn2+, and Cd2+ as toxic ions. Scientia Pharmaceutica. 2003; 71(2):75-88. https://doi.org/10.3797/scipharm.aut-03-09

Chicago/Turabian Style

EL Guindi, Nabawia M. 2003. "Composition and stability of complexes of Ephedrine hydrochloride with Ni2+, Zn2+, and Cd2+ as toxic ions" Scientia Pharmaceutica 71, no. 2: 75-88. https://doi.org/10.3797/scipharm.aut-03-09

APA Style

EL Guindi, N. M. (2003). Composition and stability of complexes of Ephedrine hydrochloride with Ni2+, Zn2+, and Cd2+ as toxic ions. Scientia Pharmaceutica, 71(2), 75-88. https://doi.org/10.3797/scipharm.aut-03-09

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