Syrltllesis and Alltituberculous activity of N-Mannich bases of 3-[4-(4 chloropheny1)-6-(4-methylphesyl) pyrimidin-2-yl] iminoisatin derivatives

Sriram D.; Yogeeswari P.; Pandeya S.N.; Ananthan S.

doi:10.3797/scipharm.aut-02-05

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Article

21 January 2002

Syrltllesis and Alltituberculous activity of N-Mannich bases of 3-[4-(4 chloropheny1)-6-(4-methylphesyl) pyrimidin-2-yl] iminoisatin derivatives

and

Medicirlal Chernistry Research Laboratoly, Phannacy Group, Birla Institute of Technology and Sciences. Pilani, Rajastban-33303 1, (INDIA)

Department of I'halnlaceutics, Institute of Technology, Banalas Hindu University, Vasanasi-221005, (INDIA)

National lrlstitute of Allergy and Infectious Diseases, TAACF, Southern Research Institute, 2000, 9th Avenue South, Birmingham, AL 35255, (USA).

Author to whom correspondence should be addressed.

Sci. Pharm.2002, 70(1), 39-48;https://doi.org/10.3797/scipharm.aut-02-05

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Simple Summary

Isatin, its 5-chloro and 5-bromo derivatives have beer) reacted with 4-(4-chloropheny1)-6-(4-methylphenyl)-2-aminopyrimidine to form Schiff bases and the N-Mannich bases of these compounds were syrlthesized by reacting thern with folmaldehyde and several secondary arnines. The cornpoullds were evaluated in vitro against Mycobacterium tuberculosis H37Rv at 6.25 μg/ml in BACTEC 12l3 tnediunl using the BACTEC 460 radiometric system. Among the cotnpounds tested 3-[4-(4-ch1orophenyl)-6-(4- methylphenyl) pyrimidin-2-yl]iminoisatin (Sl) showed prornising activity with 97% inhibition at a concentration of 6.25 μg/ml.

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Tuberculosis is making a worldwide resurgence [...]

Keywords:

Isatin; Mannich bases; Schiff bases; Antituberculous

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