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Volume 68
Issue 2
10.3797/scipharm.aut-00-17
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Article

Ion-pair Spectrophotometric Determination of Dibucaine

by
Raqi M. Shubietah
1,*,
Ali Z.Abu Zuhri
2 and
Bashar A. Khalid
2
1
Faculty of Pharmacy, An-Najah National University, P.O.Box 7, Nablus, Palestine, via Israel
2
Department of Postgraduate Studies, An-Najah National University, P.O.Box 7, Nablus, Palestine, via Israel
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2000, 68(2), 189-200; https://doi.org/10.3797/scipharm.aut-00-17
Submission received: 12 December 1999 / Revised: 4 May 2000 / Accepted: 4 May 2000 / Published: 12 May 2000
Versions Notes

Abstract

A simple and sensitive spectrophotometric determination of dibucain has been established. It is based on the formation of colored ion-pair complexes between Dibucaine and each of Orange II, Orange G, Bromothymol blue and Bromocresol green. The extract with each of the previous dyes in chloroform exhibited a specific wavelength of maximum absorbance, and all these wavelengths lied in the range 416 to 500 nm. The linear range extended from 1.5 to 60 ppm. The optimum conditions were selected after studying many variables such as pH, shaking time, temperature and dye concentrations. The method was also selective for the analyte and the drug excipients did not interfere.
Keywords: Dibucaine; Ion-pair spectrometry Dibucaine; Ion-pair spectrometry

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MDPI and ACS Style

Shubietah, R.M.; Zuhri, A.Z.A.; Khalid, B.A. Ion-pair Spectrophotometric Determination of Dibucaine. Sci. Pharm. 2000, 68, 189-200. https://doi.org/10.3797/scipharm.aut-00-17

AMA Style

Shubietah RM, Zuhri AZA, Khalid BA. Ion-pair Spectrophotometric Determination of Dibucaine. Scientia Pharmaceutica. 2000; 68(2):189-200. https://doi.org/10.3797/scipharm.aut-00-17

Chicago/Turabian Style

Shubietah, Raqi M., Ali Z.Abu Zuhri, and Bashar A. Khalid. 2000. "Ion-pair Spectrophotometric Determination of Dibucaine" Scientia Pharmaceutica 68, no. 2: 189-200. https://doi.org/10.3797/scipharm.aut-00-17

APA Style

Shubietah, R. M., Zuhri, A. Z. A., & Khalid, B. A. (2000). Ion-pair Spectrophotometric Determination of Dibucaine. Scientia Pharmaceutica, 68(2), 189-200. https://doi.org/10.3797/scipharm.aut-00-17

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