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Ion-pair Spectrophotometric Determination of Dibucaine

1
Faculty of Pharmacy, An-Najah National University, P.O.Box 7, Nablus, Palestine, via Israel
2
Department of Postgraduate Studies, An-Najah National University, P.O.Box 7, Nablus, Palestine, via Israel
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2000, 68(2), 189-200; https://doi.org/10.3797/scipharm.aut-00-17
Received: 12 December 1999 / Revised: 4 May 2000 / Accepted: 4 May 2000 / Published: 12 May 2000
A simple and sensitive spectrophotometric determination of dibucain has been established. It is based on the formation of colored ion-pair complexes between Dibucaine and each of Orange II, Orange G, Bromothymol blue and Bromocresol green. The extract with each of the previous dyes in chloroform exhibited a specific wavelength of maximum absorbance, and all these wavelengths lied in the range 416 to 500 nm. The linear range extended from 1.5 to 60 ppm. The optimum conditions were selected after studying many variables such as pH, shaking time, temperature and dye concentrations. The method was also selective for the analyte and the drug excipients did not interfere.
Keywords: Dibucaine; Ion-pair spectrometry Dibucaine; Ion-pair spectrometry
MDPI and ACS Style

Shubietah, R.M.; Zuhri, A.Z.; Khalid, B.A. Ion-pair Spectrophotometric Determination of Dibucaine. Sci. Pharm. 2000, 68, 189-200.

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