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Vaccines 2015, 3(4), 803-813;

Micelle-Based Adjuvants for Subunit Vaccine Delivery

Aix-Marseille Université, CNRS, CR UMR 7273, 13397 Marseille, France
Université Lyon 1, CNRS, LBTI UMR 5305, 69367 Lyon, France
Author to whom correspondence should be addressed.
Academic Editor: Darrell J. Irvine
Received: 29 July 2015 / Revised: 8 September 2015 / Accepted: 22 September 2015 / Published: 25 September 2015
(This article belongs to the Special Issue Nanoparticle-Based Vaccines)
Full-Text   |   PDF [259 KB, uploaded 13 October 2015]   |  


In the development of subunit vaccines with purified or recombinant antigens for cancer and infectious diseases, the design of improved and safe adjuvants able to efficiently target the antigen presenting cells, such as dendritic cells, represents a crucial challenge. Nanoparticle-based antigen delivery systems have been identified as an innovative strategy to improve the efficacy of subunit vaccines. Among them, self-assembled micellar nanoparticles from amphiphilic (macro)molecules have recently emerged as promising candidates. In this short review, we report on the recent research findings highlighting the versatility and potential of such systems in vaccine delivery. View Full-Text
Keywords: micelles; antigens; amphiphilic copolymers; peptide amphiphiles micelles; antigens; amphiphilic copolymers; peptide amphiphiles

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Trimaille, T.; Verrier, B. Micelle-Based Adjuvants for Subunit Vaccine Delivery. Vaccines 2015, 3, 803-813.

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