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Vaccines 2015, 3(1), 22-73;

Optimal Use of Vaccines for Control of Influenza A Virus in Swine

Center for Food Security and Public Health, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
Author to whom correspondence should be addressed.
Academic Editor: Sarah Gilbert
Received: 4 December 2014 / Revised: 9 January 2015 / Accepted: 19 January 2015 / Published: 30 January 2015
(This article belongs to the Special Issue Influenza Vaccines)
Full-Text   |   PDF [841 KB, uploaded 30 January 2015]   |  


Influenza A virus in swine (IAV-S) is one of the most important infectious disease agents of swine in North America. In addition to the economic burden of IAV-S to the swine industry, the zoonotic potential of IAV-S sometimes leads to serious public health concerns. Adjuvanted, inactivated vaccines have been licensed in the United States for over 20 years, and there is also widespread usage of autogenous/custom IAV-S vaccines. Vaccination induces neutralizing antibodies and protection against infection with very similar strains. However, IAV-S strains are so diverse and prone to mutation that these vaccines often have disappointing efficacy in the field. This scientific review was developed to help veterinarians and others to identify the best available IAV-S vaccine for a particular infected herd. We describe key principles of IAV-S structure and replication, protective immunity, currently available vaccines, and vaccine technologies that show promise for the future. We discuss strategies to optimize the use of available IAV-S vaccines, based on information gathered from modern diagnostics and surveillance programs. Improvements in IAV-S immunization strategies, in both the short term and long term, will benefit swine health and productivity and potentially reduce risks to public health. View Full-Text
Keywords: influenza A virus in swine; vaccines; immune response; surveillance; veterinary diagnostics influenza A virus in swine; vaccines; immune response; surveillance; veterinary diagnostics

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Sandbulte, M.R.; Spickler, A.R.; Zaabel, P.K.; Roth, J.A. Optimal Use of Vaccines for Control of Influenza A Virus in Swine. Vaccines 2015, 3, 22-73.

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