Next Article in Journal
EBV-Associated Cancer and Autoimmunity: Searching for Therapies
Next Article in Special Issue
Assaying the Potency of Influenza Vaccines
Previous Article in Journal
The Potential Impact of Preventive HIV Vaccines in China: Results and Benefits of a Multi-Province Modeling Collaboration
Previous Article in Special Issue
Overview of Serological Techniques for Influenza Vaccine Evaluation: Past, Present and Future
Open AccessReview

Optimal Use of Vaccines for Control of Influenza A Virus in Swine

Center for Food Security and Public Health, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Sarah Gilbert
Vaccines 2015, 3(1), 22-73; https://doi.org/10.3390/vaccines3010022
Received: 4 December 2014 / Revised: 9 January 2015 / Accepted: 19 January 2015 / Published: 30 January 2015
(This article belongs to the Special Issue Influenza Vaccines)
Influenza A virus in swine (IAV-S) is one of the most important infectious disease agents of swine in North America. In addition to the economic burden of IAV-S to the swine industry, the zoonotic potential of IAV-S sometimes leads to serious public health concerns. Adjuvanted, inactivated vaccines have been licensed in the United States for over 20 years, and there is also widespread usage of autogenous/custom IAV-S vaccines. Vaccination induces neutralizing antibodies and protection against infection with very similar strains. However, IAV-S strains are so diverse and prone to mutation that these vaccines often have disappointing efficacy in the field. This scientific review was developed to help veterinarians and others to identify the best available IAV-S vaccine for a particular infected herd. We describe key principles of IAV-S structure and replication, protective immunity, currently available vaccines, and vaccine technologies that show promise for the future. We discuss strategies to optimize the use of available IAV-S vaccines, based on information gathered from modern diagnostics and surveillance programs. Improvements in IAV-S immunization strategies, in both the short term and long term, will benefit swine health and productivity and potentially reduce risks to public health. View Full-Text
Keywords: influenza A virus in swine; vaccines; immune response; surveillance; veterinary diagnostics influenza A virus in swine; vaccines; immune response; surveillance; veterinary diagnostics
Show Figures

Figure 1

MDPI and ACS Style

Sandbulte, M.R.; Spickler, A.R.; Zaabel, P.K.; Roth, J.A. Optimal Use of Vaccines for Control of Influenza A Virus in Swine. Vaccines 2015, 3, 22-73.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop